Yang Hong, Huang Yunda, Jiang Guihua, Duan Zhiping, Du Runfen, Hao Yinan, Huang Wei, Liu Xiaoling
Department of Geriatrics, The Third People's Hospital of Yunnan Province, 292 Beijing Road, Kunming, 650011, Yunnan, China.
Radiotherapy Department, Yunnan Cancer Hospital, No. 519 Kunzhou Road, Kunming, 650118, Yunnan, China.
Eur Geriatr Med. 2025 Feb;16(1):55-65. doi: 10.1007/s41999-024-01111-w. Epub 2024 Dec 2.
The sarcopenia index (SI) is a convenient method to screen for sarcopenia, but few studies have analysed whether there are sex differences. The aim of this study was to analyse sex differences in the relationship between SI and sarcopenia in a Chinese community-based population.
This cross-sectional study included participants from 2011 China Health and Retirement Longitudinal Study. The SI was defined as 100 × creatinine / cystatin C. Diagnosis of sarcopenia based on the Asian Working Group for Sarcopenia 2019 consensus. Logistic regression model, linear regression model, and natural spline model were used to analyze the association between SI and sarcopenia.
A total of 7,118 participants with a mean age of 60.6 ± 10.1 were included, 53.4% females. In males, the prevalence of sarcopenia decreased by 25% for every 10 increase in SI, and skeletal muscle mass index (SMI) increased by 0.04, odds ratio (OR), β, and 95% confidence interval (CI) were 0.75 (0.65-0.87), 0.04 (0.02-0.05), both P < 0.001. In females, the SI was not significantly associated with sarcopenia, OR and 95% CI were 0.99 (0.9 ~ 1.08), P = 0.775; for every 10 increase in SI, the SMI in females decreased by 0.03, β and 95% CI were -0.03 (-0.04 ~ -0.01), P = 0.001.
In the Chinese community, the SI is negatively associated with sarcopenia in males and has moderate diagnostic test performance. It was not associated with sarcopenia in females, and using the SI to screen for sarcopenia in females may not be a reliable method.
肌少症指数（SI）是一种筛查肌少症的便捷方法，但很少有研究分析其是否存在性别差异。本研究旨在分析中国社区人群中SI与肌少症之间关系的性别差异。
这项横断面研究纳入了2011年中国健康与养老追踪调查的参与者。SI定义为100×肌酐/胱抑素C。根据2019年亚洲肌少症工作组共识诊断肌少症。采用逻辑回归模型、线性回归模型和自然样条模型分析SI与肌少症之间的关联。
共纳入7118名平均年龄为60.6±10.1岁的参与者，其中女性占53.4%。在男性中，SI每增加10，肌少症患病率下降25%，骨骼肌质量指数（SMI）增加0.04，优势比（OR）、β值和95%置信区间（CI）分别为0.75（0.65 - 0.87）、0.04（0.02 - 0.05），P均<0.001。在女性中，SI与肌少症无显著关联，OR和95%CI为0.99（0.9 - 1.08），P = 0.775；SI每增加10，女性的SMI下降0.03，β值和95%CI为 -0.03（-0.04 - -0.01），P = 0.001。
在中国社区，SI与男性肌少症呈负相关，具有中等诊断测试性能。它与女性肌少症无关，使用SI筛查女性肌少症可能不是一种可靠的方法。
