Emudianughe T S, Oduleye S O, Ebadan E E, Eneji S D
Xenobiotica. 1986 Feb;16(2):177-9. doi: 10.3109/00498258609043520.
The urinary metabolites of a single dose (1 g) of salicylic acid were investigated in black Nigerian subjects (78 females 44 males). Qualitatively, the major metabolites were the glycine and glucuronic acid conjugates. Quantitatively, there was a statistically significant difference in the level of these metabolites between female and male subjects (P less than 0.001) (using Student's t-test). The results of the present study compared with earlier published data show a statistically significant quantitative difference between black Nigerians and Caucasians (P less than 0.001). The results suggest possible racial and sex differences in the metabolism of salicylic acid.
对尼日利亚黑人受试者（78名女性，44名男性）单剂量（1克）水杨酸的尿液代谢物进行了研究。定性分析显示，主要代谢物是甘氨酸和葡萄糖醛酸结合物。定量分析表明，这些代谢物的水平在女性和男性受试者之间存在统计学显著差异（P<0.001）（采用学生t检验）。本研究结果与早期发表的数据相比，显示尼日利亚黑人和白种人之间存在统计学显著的定量差异（P<0.001）。结果表明水杨酸代谢可能存在种族和性别差异。
