Chen Yalu, Shentu Jianqiao, Lou Hanqi, Xia Yongming, Jiang Yinyan, Duan Shiwei
Department of Hematology, Yuyao People's Hospital of Zhejiang Province, The Affiliated Yangming Hospital of Ningbo University, Yuyao, 315400, Zhejiang, China.
Department of Clinical Medicine, Hangzhou City University, Hangzhou, 310015, Zhejiang, China.
Stem Cell Res Ther. 2024 Dec 2;15(1):459. doi: 10.1186/s13287-024-04084-6.
Hematopoietic stem cells (HSCs) are critical for maintaining lifelong blood production and immune function, especially in the context of bone marrow transplantation, where their ability to reconstruct multiple blood lineages is essential. However, recent studies have revealed that certain HSCs exhibit a bias toward platelet differentiation, termed platelet-biased HSCs (P-HSCs). This lineage bias, particularly pronounced with aging, can lead to imbalances in post-transplant blood recovery, negatively affecting patient outcomes. Research by Claus Nerlov's team has provided key insights into the heterogeneity of HSCs, focusing on the age-related expansion of P-HSCs. Using advanced techniques such as single-cell RNA sequencing and molecular barcoding, their work highlights the evolutionary conservation of platelet bias in HSCs across species. This work delves into these findings, discussing their clinical implications for bone marrow transplantation, aging-related blood disorders, and potential therapeutic strategies. Moreover, we address limitations in current methodologies and propose future directions for research to optimize HSC-based therapies and improve clinical outcomes in hematological diseases.
造血干细胞（HSCs）对于维持终身血液生成和免疫功能至关重要，尤其是在骨髓移植的情况下，其重建多种血液谱系的能力至关重要。然而，最近的研究表明，某些造血干细胞表现出向血小板分化的偏向，称为血小板偏向性造血干细胞（P-HSCs）。这种谱系偏向在衰老过程中尤为明显，可导致移植后血液恢复失衡，对患者预后产生负面影响。克劳斯·内洛夫团队的研究为造血干细胞的异质性提供了关键见解，重点关注血小板偏向性造血干细胞与年龄相关的扩张。通过使用单细胞RNA测序和分子条形码等先进技术，他们的工作突出了跨物种造血干细胞中血小板偏向的进化保守性。这项工作深入探讨了这些发现，讨论了它们对骨髓移植、衰老相关血液疾病的临床意义以及潜在的治疗策略。此外，我们阐述了当前方法的局限性，并提出了未来的研究方向，以优化基于造血干细胞的治疗方法并改善血液系统疾病的临床结局。
