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CYR61 Is Overexpressed in Human Melanoma Tissue and Promotes Melanoma Cell Survival and Proliferation Through Its Binding Ligand Integrin β3 .

作者信息

Lee Yoon Jin, Kim Ki Dam, Park Sukh Que, Kim Dong Sung, Choi Yu Sung, Nam Hae Seon, Lee Sang Han, Cho Moon Kyun

机构信息

Department of Biochemistry, Soonchunhyang University College of Medicine, Cheonan, Korea.

Division of Molecular Cancer Research, Soonchunhyang Medical Research Institute, Soonchunhyang University, Cheonan, Korea.

出版信息

Ann Dermatol. 2024 Dec;36(6):392-394. doi: 10.5021/ad.24.008.

DOI:10.5021/ad.24.008
PMID:39623617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11621637/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec4f/11621637/760d617f4bbf/ad-36-392-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec4f/11621637/760d617f4bbf/ad-36-392-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec4f/11621637/760d617f4bbf/ad-36-392-g001.jpg

相似文献

1
CYR61 Is Overexpressed in Human Melanoma Tissue and Promotes Melanoma Cell Survival and Proliferation Through Its Binding Ligand Integrin β3 .CYR61在人黑色素瘤组织中过表达，并通过其结合配体整合素β3促进黑色素瘤细胞的存活和增殖。
Ann Dermatol. 2024 Dec;36(6):392-394. doi: 10.5021/ad.24.008.
2
Cyr61 is a target for heparin in reducing MV3 melanoma cell adhesion and migration via the integrin VLA-4.Cyr61 是肝素通过整合素 VLA-4 减少 MV3 黑素瘤细胞黏附和迁移的作用靶点。
Thromb Haemost. 2013 Nov;110(5):1046-54. doi: 10.1160/TH13-02-0158. Epub 2013 Sep 5.
3
Identification of CD47/integrin-associated protein and alpha(v)beta3 as two receptors for the alpha3(IV) chain of type IV collagen on tumor cells.鉴定CD47/整合素相关蛋白和α(v)β3为肿瘤细胞上IV型胶原α3(IV)链的两种受体。
Cancer Res. 1999 Sep 15;59(18):4584-90.
4
CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain.CYR61通过整合素αvβ5刺激人皮肤成纤维细胞迁移，并通过整合素αvβ3增强有丝分裂，且不依赖于其羧基末端结构域。
J Biol Chem. 2001 Jun 15;276(24):21943-50. doi: 10.1074/jbc.M100978200. Epub 2001 Apr 3.
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Fibroblast growth factor-2 but not Mel-CAM and/or beta3 integrin promotes progression of melanocytes to melanoma.成纤维细胞生长因子-2而非Mel-CAM和/或β3整合素促进黑素细胞向黑色素瘤进展。
Exp Dermatol. 2003 Jun;12(3):296-306. doi: 10.1034/j.1600-0625.2003.120310.x.
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Elevated expression of Cyr61 enhances peritoneal dissemination of gastric cancer cells through integrin alpha2beta1.Cyr61的高表达通过整合素α2β1增强胃癌细胞的腹膜播散。
J Biol Chem. 2007 Nov 23;282(47):34594-604. doi: 10.1074/jbc.M706600200. Epub 2007 Sep 28.
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Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans.人皮肤成纤维细胞与Cyr61的黏附是通过整合素α6β1和细胞表面硫酸乙酰肝素蛋白聚糖介导的。
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Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival.整合素α(v)β3通过调节肿瘤细胞存活来促进人皮肤中M21黑色素瘤的生长。
Cancer Res. 1999 Jun 1;59(11):2724-30.
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Cyr61 promotes Schwann cell proliferation and migration via αvβ3 integrin.Cyr61 通过αvβ3 整合素促进许旺细胞的增殖和迁移。
BMC Mol Cell Biol. 2021 Apr 7;22(1):21. doi: 10.1186/s12860-021-00360-y.
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siRNA-mediated silencing of integrin β3 expression inhibits the metastatic potential of B16 melanoma cells.siRNA 介导的整合素 β3 表达沉默抑制 B16 黑色素瘤细胞的转移潜能。
Oncol Rep. 2012 Nov;28(5):1567-73. doi: 10.3892/or.2012.1963. Epub 2012 Aug 10.

本文引用的文献

1
CYR61 suppresses growth of human malignant melanoma.富含半胱氨酸的血管生成素61抑制人类恶性黑色素瘤的生长。
Oncol Rep. 2016 Nov;36(5):2697-2704. doi: 10.3892/or.2016.5124. Epub 2016 Sep 23.
2
Cyr61 is a target for heparin in reducing MV3 melanoma cell adhesion and migration via the integrin VLA-4.Cyr61 是肝素通过整合素 VLA-4 减少 MV3 黑素瘤细胞黏附和迁移的作用靶点。
Thromb Haemost. 2013 Nov;110(5):1046-54. doi: 10.1160/TH13-02-0158. Epub 2013 Sep 5.
3
Cyr61 is up-regulated in prostate cancer and associated with the p53 gene status.
Cyr61在前列腺癌中上调，并与p53基因状态相关。
J Cell Biochem. 2009 Mar 1;106(4):738-44. doi: 10.1002/jcb.22075.
4
Functions and mechanisms of action of CCN matricellular proteins.CCN基质细胞蛋白的功能及作用机制。
Int J Biochem Cell Biol. 2009 Apr;41(4):771-83. doi: 10.1016/j.biocel.2008.07.025. Epub 2008 Aug 15.
5
Cyr61/CCN1 is a tumor suppressor in human hepatocellular carcinoma and involved in DNA damage response.Cyr61/CCN1是人类肝细胞癌中的一种肿瘤抑制因子，并参与DNA损伤反应。
Int J Biochem Cell Biol. 2008;40(1):98-109. doi: 10.1016/j.biocel.2007.06.020. Epub 2007 Jul 26.
6
Integrin regulation.整合素调节
Curr Opin Cell Biol. 2005 Oct;17(5):509-16. doi: 10.1016/j.ceb.2005.08.010.
7
Integrin signaling in malignant melanoma.恶性黑色素瘤中的整合素信号传导
Cancer Metastasis Rev. 2005 Jun;24(2):195-222. doi: 10.1007/s10555-005-1572-1.
8
Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells.黑色素瘤细胞中血管生成因子Cyr61缺氧基因调控的机制
J Biol Chem. 2003 Nov 14;278(46):45651-60. doi: 10.1074/jbc.M301373200. Epub 2003 Aug 25.
9
Progression-related expression of beta3 integrin in melanomas and nevi.β3整合素在黑色素瘤和痣中与进展相关的表达
Hum Pathol. 1999 May;30(5):562-7. doi: 10.1016/s0046-8177(99)90202-2.
10
Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma.β3整合素亚基的腺病毒基因转移诱导原发性人类黑色素瘤从放射状生长阶段向垂直生长阶段转变。
Am J Pathol. 1998 Nov;153(5):1435-42. doi: 10.1016/s0002-9440(10)65730-6.