Honjo Yasuyuki, Nagai Kuniaki, Yuri Takuma, Nakai Hideaki, Kawasaki Ippei, Harada Shun, Suganuma Ippei, Ogawa Noriyuki
Kyoto Kaisei Hospital, Kyoto, Japan.
Department of Occupational Therapy, Kyoto Tachibana University, Kyoto, Japan.
J Appl Gerontol. 2025 Aug;44(8):1211-1217. doi: 10.1177/07334648241305306. Epub 2024 Dec 2.
Behavioral and psychological symptoms of dementia (BPSD) can appear not only in Alzheimer's disease dementia (ADD) but in mild cognitive impairment (MCI). This study examined the association of BPSD with caregiver relationship, using the Neuropsychiatric Inventory Questionnaire (NPI-Q) score. The cognitive function of 419 new outpatients with ADD or MCI was evaluated using the Revised Hasegawa Dementia Scale (HDS-R) and the Mini-Mental State Examination (MMSE). Caregiver relationship was significantly associated with patient age, sex, duration of education, cohabitation status, total NPI-Q score, and number of NPI-Q domains. Caregiver (oldest daughter), duration of school education, age, and total HDS-R and MMSE scores were significantly associated with NPI-Q total score and number of NPI-Q domains. The delusions, dysphoria/depression, irritability/lability, and aberrant motor behaviors domains were significantly associated with caregiver relationship. The dysphoria/depression and irritability/lability domain score were scored significantly higher by female caregivers. The delusion domain was significantly associated with cohabitation.
痴呆的行为和心理症状（BPSD）不仅会出现在阿尔茨海默病性痴呆（ADD）中，也会出现在轻度认知障碍（MCI）中。本研究使用神经精神科问卷（NPI-Q）评分来考察BPSD与照料者关系之间的关联。采用修订版长谷川痴呆量表（HDS-R）和简易精神状态检查表（MMSE）对419名新诊断的ADD或MCI门诊患者的认知功能进行评估。照料者关系与患者年龄、性别、受教育时长、同居状况、NPI-Q总分以及NPI-Q领域数量显著相关。照料者（最大的女儿）、受教育年限、年龄以及HDS-R和MMSE总分与NPI-Q总分及NPI-Q领域数量显著相关。妄想、烦躁/抑郁、易激惹/情绪不稳定以及异常运动行为领域与照料者关系显著相关。女性照料者的烦躁/抑郁和易激惹/情绪不稳定领域得分显著更高。妄想领域与同居状况显著相关。
