Wang Zhongjie, Hülpüsch Claudia, Traidl-Hoffmann Claudia, Reiger Matthias, Schloter Michael
Research Unit for Comparative Microbiome Analysis, Helmholtz Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Department of Environmental Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Front Med (Lausanne). 2024 Nov 18;11:1480257. doi: 10.3389/fmed.2024.1480257. eCollection 2024.
Atopic dermatitis (AD) is a prevalent inflammatory skin disorder characterized by chronic inflammation, skin barrier dysfunction, and microbial dysbiosis, with playing a significant role in its pathogenesis. This paper explores the strain diversity and microevolution of within AD patients, emphasizing how specific strains adapt to the altered skin environment, exacerbating the condition. The review emphasizes the significance of variation in specific functional genes among strains, which enhances their ability to adapt to different microenvironments and shapes their pathogenic potential. It also discusses how mobile genetic elements, particularly prophages, contribute to genetic diversity and drive the virulence and antibiotic resistance of in AD, highlighting the clinical challenges posed by these strain-specific factors in managing the disease. The paper advocates for the integration of advanced genomic tools such as whole-genome sequencing and machine learning to develop targeted therapies. By focusing on the genetic adaptability of and its impact on AD, this review underscores the need for strain-specific diagnostics and personalized treatment strategies to improve patient outcomes.
特应性皮炎（AD）是一种常见的炎症性皮肤病，其特征为慢性炎症、皮肤屏障功能障碍和微生物群落失调，[此处原文缺失关键信息]在其发病机制中起重要作用。本文探讨了AD患者体内[此处原文缺失关键信息]的菌株多样性和微观进化，强调了特定菌株如何适应改变的皮肤环境，从而加重病情。该综述强调了[此处原文缺失关键信息]菌株中特定功能基因变异的重要性，这增强了它们适应不同微环境的能力，并塑造了它们的致病潜力。它还讨论了移动遗传元件，特别是前噬菌体，如何促进遗传多样性并推动[此处原文缺失关键信息]在AD中的毒力和抗生素耐药性，突出了这些菌株特异性因素在疾病管理中带来的临床挑战。本文主张整合全基因组测序和机器学习等先进基因组工具以开发靶向治疗方法。通过关注[此处原文缺失关键信息]的遗传适应性及其对AD的影响，本综述强调了菌株特异性诊断和个性化治疗策略对于改善患者预后的必要性。
