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人类CD8 T细胞对疫苗抗原反应的异质性定量：基于HLA的视角

Quantification of heterogeneity in human CD8 T cell responses to vaccine antigens: an HLA-guided perspective.

作者信息

Harris Duane C, Shanker Apoorv, Montoya Makaela M, Llewellyn Trent R, Matuszak Anna R, Lohar Aditi, Kubicek-Sutherland Jessica Z, Li Ying Wai, Wilding Kristen, Mcmahon Ben, Gnanakaran Sandrasegaram, Ribeiro Ruy M, Perelson Alan S, Molina-París Carmen

机构信息

Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, United States.

Physical Chemistry and Applied Spectroscopy Group, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM, United States.

出版信息

Front Immunol. 2024 Nov 18;15:1420284. doi: 10.3389/fimmu.2024.1420284. eCollection 2024.

DOI:10.3389/fimmu.2024.1420284
PMID:39624092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11608996/
Abstract

Vaccines have historically played a pivotal role in controlling epidemics. Effective vaccines for viruses causing significant human disease, , Ebola, Lassa fever, or Crimean Congo hemorrhagic fever virus, would be invaluable to public health strategies and counter-measure development missions. Here, we propose coverage metrics to quantify vaccine-induced CD8 T cell-mediated immune protection, as well as metrics to characterize immuno-dominant epitopes, in light of human genetic heterogeneity and viral evolution. Proof-of-principle of our approach and methods are demonstrated for Ebola virus, SARS-CoV-2, and (vaccine) proteins.

摘要

从历史上看，疫苗在控制流行病方面发挥了关键作用。针对导致重大人类疾病的病毒，如埃博拉病毒、拉沙热病毒或克里米亚-刚果出血热病毒，有效的疫苗对于公共卫生策略和应对措施开发任务将具有不可估量的价值。在此，鉴于人类遗传异质性和病毒进化，我们提出了用于量化疫苗诱导的CD8 T细胞介导的免疫保护的覆盖指标，以及用于表征免疫优势表位的指标。我们的方法和手段的原理验证已在埃博拉病毒、严重急性呼吸综合征冠状病毒2（SARS-CoV-2）和（疫苗）蛋白上得到证明。

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