Bay W H, Ferris T F
Hypertension. 1979 Jul-Aug;1(4):410-5. doi: 10.1161/01.hyp.1.4.410.
The response of plasma renin activity (PRA) and plasma aldosterone (PA) to change in sodium intake was evaluated in pregnant women during the third trimester. After 7 days on a 10 mEq sodium diet, PRA rose from 20.6 +/- 6.2 to 59.6 +/- 11.6 ng/ml/hr and PA from 47 +/- 11 to 127 +/- 27 ng% in pregnant women compared to PRA from 5 +/- 1.2 to 18.9 +/- 5.2 ng/ml/hr and PA from 7.7 +/- 1 to 42 +/- 3 ng% in nonpregnant controls. Pregnant women conserved sodium normally with urinary sodium excretion and weight loss similar to nonpregnant women. After 6 days on a 300 mEq sodium intake, PRA and PA in pregnant women were significantly higher, 10.2 +/- 1.4 ng/ml/hr and 22 +/- 3 ng%, respectively, compared to 1.5 +/- 0.3 ng/ml/hr and 7.3 +/- 1 ng% in controls. On both low- and high sodium intake there was a positive correlation between PRA and PA in pregnant women. Plasma prostaglandin E (PGE) was 0.45 +/- 0.06 ng/ml in pregnant women compared to 0.1 +/- 0.01 ng/ml in control women (p less than 0.01) and urinary PGE excretion was 2780 +/- 357 ng/24 hr in 28 pregnant women compared to 1191 +/- 142 ng/24 hrs (p less than 0.01) in 14 nonpregnant controls. These findings indicate that although renin and aldosterone secretion respond to change in sodium intake in pregnancy, the cause of the increased renin secretion of pregnancy may be secondary to the increase that occurs in prostaglandin synthesis.
在妊娠晚期孕妇中评估了血浆肾素活性（PRA）和血浆醛固酮（PA）对钠摄入量变化的反应。与非妊娠对照组相比，孕妇在10 mEq钠饮食7天后，PRA从20.6±6.2升至59.6±11.6 ng/ml/小时，PA从47±11升至127±27 ng%；而非妊娠对照组PRA从5±1.2升至18.9±5.2 ng/ml/小时，PA从7.7±1升至42±3 ng%。孕妇通过尿钠排泄和体重减轻正常地保留钠，这与非妊娠妇女相似。在摄入300 mEq钠6天后，孕妇的PRA和PA显著更高，分别为10.2±1.4 ng/ml/小时和22±3 ng%，而对照组分别为1.5±0.3 ng/ml/小时和7.3±1 ng%。在低钠和高钠摄入时，孕妇的PRA和PA之间均呈正相关。孕妇血浆前列腺素E（PGE）为0.45±0.06 ng/ml，而对照妇女为0.1±0.01 ng/ml（p<0.01）；28名孕妇的尿PGE排泄为2780±357 ng/24小时，而14名非妊娠对照为1191±142 ng/24小时（p<0.01）。这些发现表明，尽管妊娠期间肾素和醛固酮分泌对钠摄入量变化有反应，但妊娠时肾素分泌增加的原因可能继发于前列腺素合成的增加。
