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水凝胶间隔物插入导致的直肠溃疡:一例报告并文献复习

A rectal ulcer caused by hydrogel spacer insertion: A case report and review of the literature.

作者信息

Yagi Sen, Kawano Moyu, Kawasaki Keitaro, Murakami Takatoshi, Miyaike Jiro, Furukawa Shinya

机构信息

Department of Internal Medicine Saiseikai Imabari Hospital Ehime Japan.

Health Services Center Ehime University Ehime Japan.

出版信息

DEN Open. 2024 Dec 2;5(1):e70036. doi: 10.1002/deo2.70036. eCollection 2025 Apr.

DOI:10.1002/deo2.70036
PMID:39624260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11609579/
Abstract

A 75-year-old man presented with hematochezia. He had been diagnosed with prostate cancer (stage 1) 1 month previously and had undergone gold marker injection and hydrogel spacer insertion 3 weeks previously to prepare for radiotherapy. Hydrogel spacer insertion is a safe procedure that can prevent the side effects of radiotherapy for prostate cancer. A computed tomography evaluation identified a low-density area that extended from the prostate to the rectal wall. Magnetic resonance imaging of the abdomen revealed the hydrogel spacer between the anterior rectal wall and prostate. A colonoscopy revealed an approximately 2 cm ulcer in the rectum. The patient was diagnosed with a rectal ulcer with bleeding caused by hydrogel spacer insertion. Conservative follow-up was performed, and his condition improved over time. Radiotherapy for prostate cancer was initiated 4 months after hydrogel spacer insertion. The patient has not experienced any abdominal symptoms such as bloody stools since that time. Because the incidence of prostate cancer is increasing, the number of such cases is likely to increase in the future.

摘要

一名75岁男性出现便血症状。他在1个月前被诊断为前列腺癌(1期),并在3周前接受了金标注射和水凝胶间隔物植入,为放疗做准备。水凝胶间隔物植入是一种安全的手术,可预防前列腺癌放疗的副作用。计算机断层扫描评估发现一个低密度区域,从前列腺延伸至直肠壁。腹部磁共振成像显示直肠前壁与前列腺之间有水凝胶间隔物。结肠镜检查发现直肠有一个约2厘米的溃疡。该患者被诊断为因水凝胶间隔物植入导致的直肠溃疡伴出血。进行了保守随访,其病情随时间改善。在水凝胶间隔物植入4个月后开始进行前列腺癌放疗。自那时起,患者未再出现任何腹部症状,如便血。由于前列腺癌的发病率在上升,未来此类病例数量可能会增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4026/11609579/8ace92a6cd53/DEO2-5-e70036-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4026/11609579/6e984413ae79/DEO2-5-e70036-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4026/11609579/abb4134ca9b4/DEO2-5-e70036-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4026/11609579/8ace92a6cd53/DEO2-5-e70036-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4026/11609579/6e984413ae79/DEO2-5-e70036-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4026/11609579/abb4134ca9b4/DEO2-5-e70036-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4026/11609579/8ace92a6cd53/DEO2-5-e70036-g001.jpg

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本文引用的文献

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2
Spontaneous healing of rectal penetration by SpaceOAR hydrogel insertion during permanent iodine-125 implant brachytherapy: A case report.在永久性碘-125植入近距离放射治疗期间,通过插入SpaceOAR水凝胶实现直肠穿透的自发愈合:一例报告。
Mol Clin Oncol. 2019 Dec;11(6):580-582. doi: 10.3892/mco.2019.1937. Epub 2019 Oct 15.
3
Absorbable Hydrogel Spacer Use in Prostate Radiotherapy: A Comprehensive Review of Phase 3 Clinical Trial Published Data.
可吸收水凝胶间隔物在前列腺放疗中的应用:对已发表的3期临床试验数据的全面综述
Urology. 2018 May;115:39-44. doi: 10.1016/j.urology.2017.11.016. Epub 2017 Nov 23.
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[Clinical examination of cases of radiation proctitis after intensity-modulated radiation therapy for prostate cancer].[前列腺癌调强放射治疗后放射性直肠炎病例的临床检查]
Nihon Shokakibyo Gakkai Zasshi. 2015 Jul;112(7):1299-308. doi: 10.11405/nisshoshi.112.1299.
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