Mansour Mohamed Kamal, Mohamed Ali, Raghunathan Raju
Hospital Medicine Department, Integrated Hospital Care Institute, Cleveland Clinic Abu-Dhabi, PO BOX: 112412, Abu-Dhabi, United Arab Emirates.
IDCases. 2024 Nov 13;38:e02116. doi: 10.1016/j.idcr.2024.e02116. eCollection 2024.
Colistin, a polymyxin antibiotic, is increasingly used to manage infections caused by multidrug-resistant gram-negative bacteria. This case report documents the occurrence of colistin-induced neurotoxicity manifesting as bulbar palsy in a 38-year-old male with a complex medical history. The patient, presenting with septic shock secondary to a diabetic foot ulcer, was administered colistin and meropenem, leading to a progressive onset of neurological symptoms. The timely discontinuation of colistin resulted in the complete resolution of neurotoxicity.
多粘菌素是一种多粘菌素类抗生素，越来越多地用于治疗由多重耐药革兰氏阴性菌引起的感染。本病例报告记录了一名38岁男性患者发生多粘菌素诱导的神经毒性，表现为延髓麻痹，该患者有复杂的病史。该患者因糖尿病足溃疡继发感染性休克，接受了多粘菌素和美罗培南治疗，随后出现进行性神经症状。及时停用多粘菌素后，神经毒性完全消失。
