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黏菌素诱发的延髓麻痹性神经毒性。病例报告及文献综述。

Colistin induced neurotoxicity with bulbar palsy. A case report and literature review.

作者信息

Mansour Mohamed Kamal, Mohamed Ali, Raghunathan Raju

机构信息

Hospital Medicine Department, Integrated Hospital Care Institute, Cleveland Clinic Abu-Dhabi, PO BOX: 112412, Abu-Dhabi, United Arab Emirates.

出版信息

IDCases. 2024 Nov 13;38:e02116. doi: 10.1016/j.idcr.2024.e02116. eCollection 2024.

Abstract

Colistin, a polymyxin antibiotic, is increasingly used to manage infections caused by multidrug-resistant gram-negative bacteria. This case report documents the occurrence of colistin-induced neurotoxicity manifesting as bulbar palsy in a 38-year-old male with a complex medical history. The patient, presenting with septic shock secondary to a diabetic foot ulcer, was administered colistin and meropenem, leading to a progressive onset of neurological symptoms. The timely discontinuation of colistin resulted in the complete resolution of neurotoxicity.

摘要

多粘菌素是一种多粘菌素类抗生素,越来越多地用于治疗由多重耐药革兰氏阴性菌引起的感染。本病例报告记录了一名38岁男性患者发生多粘菌素诱导的神经毒性,表现为延髓麻痹,该患者有复杂的病史。该患者因糖尿病足溃疡继发感染性休克,接受了多粘菌素和美罗培南治疗,随后出现进行性神经症状。及时停用多粘菌素后,神经毒性完全消失。

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