Musicante Meryl, Ferrer James, Lin Jianjian, Patel Tejesh Surendr, Liu-Smith Feng
College of Medicine University of Tennessee Health Science Center Memphis Tennessee USA.
Department of Dermatology College of Medicine University of Tennessee Health Science Center Memphis Tennessee USA.
Skin Health Dis. 2024 Nov 2;4(6):e463. doi: 10.1002/ski2.463. eCollection 2024 Dec.
The bodily distribution of melanoma is frequently reported without consideration of the skin surface area, which could be misleading in melanoma risk regarding anatomical sites.
To gain insights into the melanoma distribution on the body surface when the body surface area is considered.
Cutaneous melanoma data were extracted from a single dermatopathology laboratory, and the relative density from each body site was calculated by taking into consideration the skin surface area. Data from a previous publication were analyzed as a validation. Surveillance, Epidemiology and End Results Program data were also used for comparison.
Relative tumour density (RTD) of melanoma in men and women exhibits a moderate head-to-toe linear gradient, with the upper body sites showing higher density than the lower body sites in general. In particular, the ear and face show the highest RTD while the least UVR (ultraviolet radiation)-exposed buttock, abdomen and groin have the lowest, followed by the thigh and lower legs. The trend is similar in both sexes, but more obvious for men.
It was well documented that the trunk and lower legs are the most frequently diagnosed sites for men and women, respectively. However, when the surface area is considered, the melanoma distribution exhibits a rough head-to-toe gradient, which perhaps reflects a combined effect of solar UVR and clothing coverage. UVR protection on the face and ear should be emphasized as these are the sites with the highest RTDs.
黑色素瘤的身体分布情况经常在未考虑皮肤表面积的情况下被报道，这在黑色素瘤风险方面可能会对解剖部位产生误导。
在考虑皮肤表面积的情况下，深入了解黑色素瘤在体表的分布情况。
从一个单一的皮肤病理学实验室提取皮肤黑色素瘤数据，并通过考虑皮肤表面积来计算每个身体部位的相对密度。对之前一篇出版物的数据进行分析作为验证。监测、流行病学和最终结果计划的数据也用于比较。
男性和女性黑色素瘤的相对肿瘤密度（RTD）呈现出适度的从头到脚线性梯度，总体上身体上部部位的密度高于下部部位。特别是，耳朵和面部的RTD最高，而紫外线辐射暴露最少的臀部、腹部和腹股沟的RTD最低，其次是大腿和小腿。两性的趋势相似，但男性更为明显。
有充分文献记载，躯干和小腿分别是男性和女性最常被诊断出黑色素瘤的部位。然而，当考虑表面积时，黑色素瘤的分布呈现出大致的从头到脚梯度，这可能反映了太阳紫外线辐射和衣物覆盖的综合影响。应强调对面部和耳朵的紫外线防护，因为这些是RTD最高的部位。
