Hussein Ramadan S, Dayel Salman Bin, Abahussein Othman, El-Sherbiny Abeer Ali
Department of Dermatology College of Medicine Prince Sattam Bin Abdulaziz University Al-Kharj Saudi Arabia.
Department of Medical Laboratory College of Applied Medical Sciences Prince Sattam Bin Abdulaziz University Al-Kharj Saudi Arabia.
Skin Health Dis. 2024 Nov 24;4(6):e472. doi: 10.1002/ski2.472. eCollection 2024 Dec.
Minoxidil, originally developed as an antihypertensive medication, has evolved into a versatile therapeutic agent within dermatology, notably for its effectiveness in promoting hair growth. Despite its widespread use, understanding its precise mechanism of action remains a challenge. This paper addresses this gap by providing a comprehensive review of pharmacological properties, action mechanisms, clinical effectiveness and side effects associated with topical minoxidil. Furthermore, it highlights emerging trends and applications, including its role in treating androgenetic alopecia, its potential for alopecia areata management and its utilization in combination therapies. Additionally, this paper explores novel applications in scar treatment and wound healing. By synthesizing current knowledge and insights, this review adds clarity to the diverse applications of minoxidil, providing valuable guidance for clinicians and researchers aiming to optimize its therapeutic use in dermatology.
米诺地尔最初是作为一种抗高血压药物开发的，如今已在皮肤科发展成为一种多功能治疗剂，尤其因其在促进头发生长方面的有效性而闻名。尽管其应用广泛，但了解其确切作用机制仍然是一项挑战。本文通过全面综述局部用米诺地尔的药理特性、作用机制、临床疗效和副作用，填补了这一空白。此外，本文还强调了新出现的趋势和应用，包括其在治疗雄激素性脱发中的作用、在斑秃治疗中的潜力以及在联合治疗中的应用。此外，本文还探讨了其在瘢痕治疗和伤口愈合方面的新应用。通过综合当前的知识和见解，本综述阐明了米诺地尔的多种应用，为旨在优化其在皮肤科治疗应用的临床医生和研究人员提供了有价值的指导。
