Nie Zong-Yang, Hu Wei, Li Ling-Yu, Zhang Qing-Bo, Huang Xin, Li Bo
Jiangxi Qiushi Forensic Appraisal Center, Nanchang 330006, China.
Fa Yi Xue Za Zhi. 2024 Aug 25;40(4):340-351. doi: 10.12116/j.issn.1004-5619.2023.330101.
To establish the structural confirmation methods of three suspected new psychoactive substances (NPSs), and explore a more general qualitative testing method.
Infrared absorption spectroscopy (IR), gas chromatography-mass spectrometry (GC-MS), H-nuclear magnetic resonance spectroscopy (H-NMR), C-nuclear magnetic resonance spectroscopy (C-NMR), F-nuclear magnetic resonance spectroscopy (F-NMR) and other techniques were used to identify the composition and structure of 5 samples containing suspected NPS submitted by public security bureaus.
NPSs were found in the above 5 samples, and 3 were confirmed as NPS included in the newly listed controlled substances on July 1, 2024, namely 2-(methylamino)-2-(2-methylphenyl)cyclohexan-1-one (2-MDCK), 2-(ethylamino)-2-(2-fluorophenyl)cyclohexan-l-one (2-FXE), 1-(3,4-methylenedioxyphenyl)-2-(dimethylamino)pentan-1-one (dipentylone), respectively. The first two substances were phencyclidine NPS, and the third substance was synthetic cathinone NPS.
This study systematically summarizes the distinguishing features of the infrared absorption spectrometry, nuclear magnetic resonance spectroscopy and mass spectrometry of three NPSs, which can provide a reference for the qualitative identification of unknown substances.
建立三种疑似新型精神活性物质（NPS）的结构确证方法，并探索一种更通用的定性检测方法。
采用红外吸收光谱（IR）、气相色谱 - 质谱联用（GC - MS）、氢核磁共振光谱（H - NMR）、碳核磁共振光谱（C - NMR）、氟核磁共振光谱（F - NMR）等技术对公安局送检的5份含有疑似NPS的样品进行成分和结构鉴定。
在上述5份样品中检出NPS，其中3种被确认为2024年7月1日新列管的NPS，分别为2 - （甲氨基） - 2 - （2 - 甲基苯基）环己酮（2 - MDCK）、2 - （乙氨基） - 2 - （2 - 氟苯基）环己酮（2 - FXE）、1 - （3,4 - 亚甲基二氧苯基） - 2 - （二甲基氨基）戊酮（二苯戊酮）。前两种物质为苯环己哌啶类NPS，第三种物质为合成卡西酮类NPS。
本研究系统总结了三种NPS的红外吸收光谱、核磁共振光谱及质谱的鉴别特征，可为未知物质的定性鉴定提供参考。
