Lok Charmaine E, Yuo Theodore, Lee Timmy
Department of Medicine, Division of Nephrology, University Health Network, Toronto, and University of Toronto, Toronto, Ontario, Canada.
Division of Vascular Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Am J Kidney Dis. 2025 Feb;85(2):236-252. doi: 10.1053/j.ajkd.2024.05.021. Epub 2024 Dec 3.
The majority of patients with kidney failure requiring replacement therapy will need the support of hemodialysis during their journey with kidney failure. A reliable functioning vascular access is required to provide hemodialysis. This Core Curriculum reviews the major forms of vascular access (arteriovenous fistula, arteriovenous graft, and central venous catheter) as well as the planning, preparation, creation, use, and maintenance of vascular access, requiring a P-L-A-N (Patient ESKD Life-Plan first then Access Needs) for each patient. The end-stage kidney disease Patient Life-Plan focuses on a strategy for kidney replacement modalities, while the Access Needs are the corresponding dialysis access(es) and management plans. The Access Needs include a vessel preservation plan, creation plan, contingency (complications) plan, and access succession plan. Stenosis and thrombosis are common problems with arteriovenous accesses, and dysfunction and infection are common problems with central venous catheters. Underrecognized and underreported but potentially life-threatening situations include arteriovenous access rupture and high-output cardiac failure. Effective management of these and other vascular access problems requires a coordinated multidisciplinary effort that is patient centered while preserving vascular access.
大多数需要替代治疗的肾衰竭患者在其肾衰竭病程中都需要血液透析的支持。进行血液透析需要可靠的血管通路。本核心课程回顾了血管通路的主要形式(动静脉内瘘、动静脉移植物和中心静脉导管)以及血管通路的规划、准备、建立、使用和维护,要求针对每位患者制定一个P-L-A-N(患者ESKD生命计划优先,然后是通路需求)。终末期肾病患者生命计划侧重于肾脏替代方式的策略,而通路需求则是相应的透析通路和管理计划。通路需求包括血管保护计划、建立计划、应急(并发症)计划和通路接续计划。动静脉通路的常见问题是狭窄和血栓形成,中心静脉导管的常见问题是功能障碍和感染。未被充分认识和报告但可能危及生命的情况包括动静脉通路破裂和高输出量心力衰竭。有效管理这些及其他血管通路问题需要以患者为中心、同时保留血管通路的多学科协调努力。