Pasqualini J R, Nguyen B L, Mayrand C, Lecerf F
Acta Endocrinol (Copenh). 1986 Mar;111(3):378-86. doi: 10.1530/acta.0.1110378.
Tamoxifen (TAM) alone or combined with oestradiol (E2) or progesterone (P) was administered to newborn guinea pigs (2 days old) for short (2 days) or a long (12 days) treatment period. TAM alone provoked a great stimulatory effect on uterine growth and DNA content and the effect was particularly intense after the long treatment. These actions were markedly enhanced when TAM was administered together with E2. Following short treatment, the values of the uterine wet weights (mg +/- SD) were as follows: control animals, 142 +/- 15; animals treated with TAM, 298 +/- 53; E2, 335 +/- 15; (TAM + E2), 362 +/- 16. The values after the long treatment were 177 +/- 30, 555 +/- 93, 709 +/- 117 and 1263 +/- 222, respectively. Histological studies showed that TAM provoked morphological changes in both the endometrium and the myometrium. The effects were particularly great on the height of the luminal epithelial cells and on the uterine glands. After 2 days of treatment with E2, TAM and P, the thickness of the luminal epithelium, which was 13.5 micron +/- 1.5 in the control animals, increased as follows: TAM, 19 microns +/- 1.7; E2, 20.3 microns +/- 3.3; (TAM + E2), 30.5 microns +/- 5; P, 12 microns +/- 0.9 and (P + TAM), 19.7 microns +/- 1.2. The values after the 12 day treatment were: controls, 20.8 microns +/- 1.8; TAM, 27.4 microns +/- 2.1; E2, 32 +/- 3; (TAM + E2), 43 microns +/- 5; P, 17.8 microns +/- 1.2 and (P + TAM), 23.6 microns +/- 1.5.(ABSTRACT TRUNCATED AT 250 WORDS)
将他莫昔芬（TAM）单独或与雌二醇（E2）或孕酮（P）联合使用，对新生豚鼠（2日龄）进行短期（2天）或长期（12天）治疗。单独使用TAM对子宫生长和DNA含量有很大的刺激作用，长期治疗后这种作用尤为强烈。当TAM与E2一起给药时，这些作用明显增强。短期治疗后，子宫湿重（mg±标准差）的值如下：对照动物，142±15；用TAM治疗的动物，298±53；E2，335±15；（TAM+E2），362±16。长期治疗后的数值分别为177±30、555±93、709±117和1263±222。组织学研究表明，TAM引起子宫内膜和子宫肌层的形态学变化。对腔上皮细胞高度和子宫腺体的影响尤为显著。用E2、TAM和P治疗2天后，对照动物腔上皮厚度为13.5微米±1.5，增加情况如下：TAM，19微米±1.7；E2，20.3微米±3.3；（TAM+E2），30.5微米±5；P，12微米±0.9；（P+TAM），19.7微米±1.2。12天治疗后的数值为：对照，20.8微米±1.8；TAM，27.4微米±2.1；E2，32±3；（TAM+E2），43微米±5；P，17.8微米±1.2；（P+TAM），23.6微米±1.5。（摘要截于250字）
