胰脂肪酶缓释胶囊改善慢性胰腺炎或胰腺手术后外分泌性胰腺功能不全患者的排便频率和粪便稠度：双盲随机试验中患者报告的每日症状的事后分析 - Suppr

Pancrelipase Delayed-Release Capsules Improve Stool Frequency and Consistency in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis or Pancreatic Surgery: Posthoc Analysis of Patient-Reported Daily Symptoms in a Double-Blind Randomized Trial.

作者信息

Barkin Jodie A, Kort Jens J, Barkin Jamie S

机构信息

From the Department of Medicine, Division of Digestive Health and Liver Diseases, University of Miami, Leonard M. Miller School of Medicine. Miami, FL.

AbbVie, Inc., Mettawa, IL.

出版信息

Pancreas. 2025 Mar 1;54(3):e278-e280. doi: 10.1097/MPA.0000000000002423. Epub 2024 Dec 3.

DOI:10.1097/MPA.0000000000002423

PMID:39626167

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11882164/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dd6/11882164/35d8c3e18d25/pancreas-54-e278-g001.jpg

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Pancrelipase Delayed-Release Capsules Improve Stool Frequency and Consistency in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis or Pancreatic Surgery: Posthoc Analysis of Patient-Reported Daily Symptoms in a Double-Blind Randomized Trial.

Pancreas. 2025 Mar 1;54(3):e278-e280. doi: 10.1097/MPA.0000000000002423. Epub 2024 Dec 3.

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A comparison of the efficacy and tolerance of pancrelipase and placebo in the treatment of steatorrhea in cystic fibrosis patients with clinical exocrine pancreatic insufficiency.

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Safety and tolerability of a new formulation of pancrelipase delayed-release capsules (CREON) in children under seven years of age with exocrine pancreatic insufficiency due to cystic fibrosis: an open-label, multicentre, single-treatment-arm study.

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Randomised clinical trial: the efficacy and safety of pancreatin enteric-coated minimicrospheres (Creon 40000 MMS) in patients with pancreatic exocrine insufficiency due to chronic pancreatitis--a double-blind, placebo-controlled study.

Aliment Pharmacol Ther. 2012 Sep;36(5):426-36. doi: 10.1111/j.1365-2036.2012.05202.x. Epub 2012 Jul 4.

The effects of oral pancreatic enzymes (Creon 10 capsule) on steatorrhea: a multicenter, placebo-controlled, parallel group trial in subjects with chronic pancreatitis.

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本文引用的文献

Effect of Pancrelipase Therapy on Exocrine Pancreatic Insufficiency Symptoms and Coefficient of Fat Absorption Associated With Chronic Pancreatitis.

Pancreas. 2021 Feb 1;50(2):176-182. doi: 10.1097/MPA.0000000000001733.

ACG Clinical Guideline: Chronic Pancreatitis.

Am J Gastroenterol. 2020 Mar;115(3):322-339. doi: 10.14309/ajg.0000000000000535.

Pancreatic Enzyme Replacement Therapy: A Concise Review.

JOP. 2019;20(5):121-125. Epub 2019 Jul 30.

Exocrine pancreatic insufficiency: prevalence, diagnosis, and management.

Clin Exp Gastroenterol. 2019 Mar 21;12:129-139. doi: 10.2147/CEG.S168266. eCollection 2019.

Psychometric evaluation of a patient-reported outcome measure in pancreatic exocrine insufficiency (PEI).

Pancreatology. 2019 Jan;19(1):182-190. doi: 10.1016/j.pan.2018.11.013. Epub 2018 Nov 27.

Pancreatic Enzyme Supplements Are Not Effective for Relieving Abdominal Pain in Patients with Chronic Pancreatitis: Meta-Analysis and Systematic Review of Randomized Controlled Trials.

Can J Gastroenterol Hepatol. 2016;2016:8541839. doi: 10.1155/2016/8541839. Epub 2016 Apr 24.

Enzyme replacement therapy for pancreatic insufficiency: present and future.

Clin Exp Gastroenterol. 2011;4:55-73. doi: 10.2147/CEG.S17634. Epub 2011 May 4.

Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial.

Am J Gastroenterol. 2010 Oct;105(10):2276-86. doi: 10.1038/ajg.2010.201. Epub 2010 May 25.

Pancreatic enzymes for chronic pancreatitis.

Cochrane Database Syst Rev. 2009 Oct 7(4):CD006302. doi: 10.1002/14651858.CD006302.pub2.

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Pancrelipase Delayed-Release Capsules Improve Stool Frequency and Consistency in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis or Pancreatic Surgery: Posthoc Analysis of Patient-Reported Daily Symptoms in a Double-Blind Randomized Trial.

作者信息

Barkin Jodie A, Kort Jens J, Barkin Jamie S

机构信息

From the Department of Medicine, Division of Digestive Health and Liver Diseases, University of Miami, Leonard M. Miller School of Medicine. Miami, FL.

AbbVie, Inc., Mettawa, IL.

出版信息

Pancreas. 2025 Mar 1;54(3):e278-e280. doi: 10.1097/MPA.0000000000002423. Epub 2024 Dec 3.

DOI:10.1097/MPA.0000000000002423

PMID:39626167

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11882164/

Abstract

摘要

Pancrelipase Delayed-Release Capsules Improve Stool Frequency and Consistency in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis or Pancreatic Surgery: Posthoc Analysis of Patient-Reported Daily Symptoms in a Double-Blind Randomized Trial.

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Pancrelipase Delayed-Release Capsules Improve Stool Frequency and Consistency in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis or Pancreatic Surgery: Posthoc Analysis of Patient-Reported Daily Symptoms in a Double-Blind Randomized Trial.

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