Tang Rui, Wu Haisheng, Jiang Ling, Zhou Jie, Gao Xia, Zheng Jiazhen, Tang Ya-Ping, Tang Mingxi
Department of Pathology, Yaan People's Hospital (Yaan Hospital of West China Hospital of Sichuan University), Yaan 625000, China; Department of Pathology, The Affiliated Hospital, Southwest Medical University, Luzhou 646000, China.
School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, 999077, Hong Kong.
Ecotoxicol Environ Saf. 2025 Jan 1;289:117449. doi: 10.1016/j.ecoenv.2024.117449. Epub 2024 Dec 2.
The role of biological aging in the relationship between household air pollution (HAP) from polluting cooking fuels and neuropsychiatric diseases remains unclear.
This nationwide cohort study enrolled 8550 participants aged 45-80 from 2011 to 2020. Biological age based on Klemera-Doubal method (KDM-BA) was derived from 11 clinical biomarkers. The associations of switching cooking fuels with KDM-BA acceleration (KDM-BAA) and neuropsychiatric diseases were elucidated by generalized linear models and Cox proportional hazard models, respectively. The mediating effects of KDM-BAA on associations between polluting cooking fuel and neuropsychiatric diseases were further examined. We also evaluated the potential of leisure engagement in attenuating KDM-BAA associated with polluting cooking fuels.
Compared to consistent use of cleaner fuels, consistent solid fuel use was associated with a 0.12 (95 % CI: 0.05, 0.18) year increase in KDM-BAA, a 25 % higher risk of neurological disease (HR = 1.25, 95 % CI: 1.03, 1.54), and a 34 % increased risk of psychiatric disorders (HR = 1.34, 95 % CI: 1.02, 1.78). Mediation analysis revealed that KDM-BAA significantly mediated the association between solid cooking fuel and neuropsychiatric diseases, with mediated proportions of 5.96 % (P = 0.006) for neurological disease and 5.71 % (P = 0.024) for psychiatric disease. Leisure engagement demonstrated stable benefits in attenuating KDM-BAA independently of cooking fuel use.
Our findings illuminate the pathways connecting HAP from solid fuel consumption with biological aging and neuropsychiatric disorders, and highlight the role of leisure engagement and expanding access to cleaner fuels in mitigating these adverse effects.
生物衰老在使用污染性烹饪燃料产生的家庭空气污染（HAP）与神经精神疾病之间的关系中所起的作用尚不清楚。
这项全国性队列研究在2011年至2020年间纳入了8550名年龄在45至80岁之间的参与者。基于克莱梅拉-杜巴尔方法（KDM）得出的生物年龄（KDM-BA）源自11种临床生物标志物。分别通过广义线性模型和Cox比例风险模型阐明了更换烹饪燃料与KDM-BA加速（KDM-BAA）以及神经精神疾病之间的关联。进一步研究了KDM-BAA在污染性烹饪燃料与神经精神疾病关联中的中介作用。我们还评估了休闲活动在减轻与污染性烹饪燃料相关的KDM-BAA方面的潜力。
与持续使用清洁燃料相比，持续使用固体燃料与KDM-BAA增加0.12年（95%CI：0.05，0.18）、神经疾病风险高25%（HR = 1.25，95%CI：1.03，1.54）以及精神疾病风险增加34%（HR = 1.34，95%CI：1.02，1.78）相关。中介分析表明，KDM-BAA显著介导了固体烹饪燃料与神经精神疾病之间的关联，神经疾病的介导比例为5.96%（P = 0.00），精神疾病的介导比例为5.71%（P = 0.024）。休闲活动显示出在减轻KDM-BAA方面的稳定益处，且与烹饪燃料使用无关。
我们的研究结果阐明了固体燃料消费产生的HAP与生物衰老和神经精神障碍之间的联系途径，并强调了休闲活动以及扩大清洁燃料获取途径在减轻这些不利影响方面的作用。
