Children exhibit a robust B-cell response to Omicron BA.2 after breakthrough infection with limited influence from the original antigenic sin.
作者信息
Ling Zhiyang, Zheng Zhangqian, Xu Lingli, Yi Chunyan, Dong Xinran, Gu Xiaoqiong, Sun Xiaoyu, Wu Bingbing, Sun Bing, Zhou Wenhao
机构信息
State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Children's Hospital of Fudan University, Shanghai, China.
出版信息
Cell Mol Immunol. 2025 Jan;22(1):127-130. doi: 10.1038/s41423-024-01241-y. Epub 2024 Dec 3.
Abstract
摘要
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本文引用的文献
1
Reduced clinical severity during 2022 Shanghai Spring epidemic of SARS-CoV-2 omicron BA.2 variant infection-an integrated account of virus pathogenicity and vaccination effectiveness.
Natl Sci Rev. 2024 Jan 15;11(4):nwae011. doi: 10.1093/nsr/nwae011. eCollection 2024 Apr.
2
Immune imprinting and next-generation coronavirus vaccines.
Nat Microbiol. 2023 Nov;8(11):1971-1985. doi: 10.1038/s41564-023-01505-9. Epub 2023 Nov 6.
3
Immunological imprinting of humoral immunity to SARS-CoV-2 in children.
Nat Commun. 2023 Jun 29;14(1):3845. doi: 10.1038/s41467-023-39575-2.
4
Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection.
Cell Res. 2023 Mar;33(3):258-261. doi: 10.1038/s41422-023-00781-8. Epub 2023 Jan 25.
5
Broad strategies for neutralizing SARS-CoV-2 and other human coronaviruses with monoclonal antibodies.
Sci China Life Sci. 2023 Apr;66(4):658-678. doi: 10.1007/s11427-022-2215-6. Epub 2022 Nov 24.
6
Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections.
Nat Commun. 2022 Nov 19;13(1):7120. doi: 10.1038/s41467-022-34400-8.
7
Comparative global B cell receptor repertoire difference induced by SARS-CoV-2 infection or vaccination via single-cell V(D)J sequencing.
Emerg Microbes Infect. 2022 Dec;11(1):2007-2020. doi: 10.1080/22221751.2022.2105261.
8
Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2.
Nat Microbiol. 2022 Jul;7(7):1063-1074. doi: 10.1038/s41564-022-01155-3. Epub 2022 Jun 30.
9
Immune boosting by B.1.1.529 Omicron) depends on previous SARS-CoV-2 exposure.
Science. 2022 Jul 15;377(6603):eabq1841. doi: 10.1126/science.abq1841.
10
Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients.
Sci Immunol. 2021 Aug 10;6(62). doi: 10.1126/sciimmunol.abg5021.
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