Huang Chao-Feng, Ma Yingtang
Key Laboratory of Plant Design, Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
Key Laboratory of Plant Design, Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
Plant Commun. 2025 Feb 10;6(2):101200. doi: 10.1016/j.xplc.2024.101200. Epub 2024 Dec 2.
Aluminum (Al) toxicity poses a significant challenge for plant production on acidic soils, which constitute approximately 30% of the world's ice-free land. To combat Al toxicity, plants have evolved both external and internal detoxification mechanisms. The zinc-finger transcription factor STOP1 (SENSITIVE TO PROTON RHIZOTOXICITY 1) plays a critical and conserved role in Al resistance by inducing genes involved in both external exclusion and internal detoxification mechanisms. Recent studies have uncovered multiple layers of post-transcriptional regulation of STOP1 and have elucidated mechanisms by which plants sense Al and activate signaling cascades that regulate STOP1 function. This review offers a comprehensive overview of the mechanisms through which STOP1 and its homologs confer Al resistance in plants, with a particular focus on Arabidopsis thaliana and rice. Additionally, we discuss recent advances and future perspectives in understanding the post-transcriptional regulation of STOP1, as well as the Al sensing and signaling pathways upstream of STOP1.
铝（Al）毒性对酸性土壤上的植物生产构成了重大挑战，酸性土壤约占全球无冰陆地的30%。为了对抗铝毒性，植物进化出了外部和内部解毒机制。锌指转录因子STOP1（对质子根毒性敏感1）通过诱导参与外部排斥和内部解毒机制的基因，在铝抗性中发挥关键且保守的作用。最近的研究揭示了STOP1转录后调控的多个层面，并阐明了植物感知铝并激活调节STOP1功能的信号级联反应的机制。本综述全面概述了STOP1及其同源物赋予植物铝抗性的机制，特别关注拟南芥和水稻。此外，我们还讨论了在理解STOP1转录后调控以及STOP1上游的铝感知和信号通路方面的最新进展和未来展望。
