McGarry Jennifer Louise, Quirke Ned, Neary Colm, Walsh Ruth, O'Connell Robert Michael, McEntee Gerry, Conneely John Barry
Department of Hepatobiliary Surgery, Mater Misericordiae University Hospital, Dublin, Ireland.
J Surg Oncol. 2025 Apr;131(5):842-850. doi: 10.1002/jso.28026. Epub 2024 Dec 3.
It is unknown if textbook outcomes (TBOs) correlate with patient-reported health-related quality of life (HRQoL) parameters in patients undergoing hepatic resection for colorectal liver metastasises. Understanding this relationship is required to inform treatment decisions and optimise patient care. This single-centre analysis aims to assess this correlation and provide insight into the impact of liver resection on patient well-being in this population.
Single-centre analysis of all liver resections performed for colorectal liver metastases (CRLM) at our centre from 2018 to 2023. The EuroQol-5D (EQ-5D) validated telephone questionnaire was used to assess HRQoL. The impact of a TBO on overall survival and recurrence-free survival was investigated using Kaplan-Meier curve analysis. A Cox model was used to determine factors associated with improved survival.
185 patients underwent liver resection for CRLM between 2018 and 2023. 55% of eligible patients completed the EQ-5D telephone questionnaire. TBOs were achieved in 68.2% of CRLM at our institution. Achieving TBOs in this cohort was associated with improved HRQoL (p = 0.061).
This study demonstrates excellent long-term HRQoL in patients who undergo resection for CRLM. Achieving TBO in this cohort is associated with improved patient-reported HRQoL. Our findings strengthen the utility of the previously defined textbook outcomes in CRLM.
对于接受结直肠癌肝转移肝切除术的患者，教科书式的手术结果（TBOs）是否与患者报告的健康相关生活质量（HRQoL）参数相关尚不清楚。了解这种关系对于指导治疗决策和优化患者护理至关重要。这项单中心分析旨在评估这种相关性，并深入了解肝切除术对该人群患者幸福感的影响。
对2018年至2023年在我们中心进行的所有结直肠癌肝转移（CRLM）肝切除术进行单中心分析。使用经过验证的欧洲五维健康量表（EQ-5D）电话问卷来评估HRQoL。使用Kaplan-Meier曲线分析研究TBO对总生存期和无复发生存期的影响。使用Cox模型确定与生存改善相关的因素。
2018年至2023年期间，185例患者接受了CRLM肝切除术。55%符合条件的患者完成了EQ-5D电话问卷。在我们机构，68.2%的CRLM实现了TBOs。在该队列中实现TBOs与HRQoL改善相关（p = 0.061）。
本研究表明，接受CRLM切除术的患者具有出色的长期HRQoL。在该队列中实现TBO与患者报告的HRQoL改善相关。我们的研究结果强化了先前定义的CRLM教科书式手术结果的实用性。
