Rasouli Sharareh, Alizadeh Severi Ali, Abdolsamadi Mohammad, Mohassel Yaser, Safari Fatemeh, Salari Farhad, Mahdieh Nejat, Ahdi Khosroshahi Shiva, Akbari Bahman
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Medical Biotechnology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Genet Test Mol Biomarkers. 2024 Dec;28(12):485-491. doi: 10.1089/gtmb.2024.0395. Epub 2024 Dec 4.
Obstructive sleep apnea (OSA) syndrome is a widespread multifactorial disorder that raises the risk of cardiovascular disease, diabetes, and Alzheimer's disease. This study aimed to investigate the association between the risk of OSA and two C-reactive protein (CRP) gene variants, rs1130864 and rs2794521. In this study, 100 patients and 100 controls participated. Among 500 patients with OSA attending the sleep disorder center, 100 were randomly selected from those with apnea/hypopnea symptoms and daytime sleepiness. Polymerase chain reaction and restriction fragment length polymorphism of the CRP gene polymorphisms were used in this investigation. The frequency of the mutant C allele was higher in the patient group than in the control group for the rs2794521 CRP gene variant ( ≤ 0.001), and the C allele elevated the risk of OSA by 2.584 times (odds ratios = 2.584, 95% confidence interval). The frequency of the mutant T allele was higher in the patient group than in the control group for the rs1130864 CRP gene variant, while the frequency of the C allele was higher in the control group, and this difference was statistically significant ( ≤ 0.001). Our findings indicated that rs1130864 and rs2794521 of the CRP gene are associated with increased risk for OSA. Extensive research is required to determine the role of distinct CRP gene variants in OSA.
阻塞性睡眠呼吸暂停（OSA）综合征是一种广泛存在的多因素疾病，会增加心血管疾病、糖尿病和阿尔茨海默病的发病风险。本研究旨在调查OSA风险与两种C反应蛋白（CRP）基因变异rs1130864和rs2794521之间的关联。在本研究中，100名患者和100名对照参与其中。在500名到睡眠障碍中心就诊的OSA患者中，从有呼吸暂停/低通气症状和日间嗜睡的患者中随机选取100名。本调查采用聚合酶链反应和CRP基因多态性的限制性片段长度多态性分析。对于rs2794521 CRP基因变异，患者组中突变型C等位基因的频率高于对照组（≤0.001），C等位基因使OSA风险升高2.584倍（比值比 = 2.584，95%置信区间）。对于rs1130864 CRP基因变异，患者组中突变型T等位基因的频率高于对照组，而对照组中C等位基因的频率更高，且这种差异具有统计学意义（≤0.001）。我们的研究结果表明，CRP基因的rs1130864和rs2794521与OSA风险增加有关。需要进行广泛研究以确定不同CRP基因变异在OSA中的作用。
