氧化还原辅助因子所发挥的特定作用。
A specialized role played by a redox cofactor.
作者信息
Xie Shengling, Zhang Lihan
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310058, Zhejiang Province, China.
Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, School of Science, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.
出版信息
Eng Microbiol. 2022 Jan 10;2(1):100010. doi: 10.1016/j.engmic.2022.100010. eCollection 2022 Mar.
The redox cofactor β-nicotinamide adenine dinucleotide (NAD) has been revealed to serve as a building block for the biosynthesis of an alkaloid natural product, altemicidin. The biosynthetic pathway investigation identified a unique pyridoxal pyrophosphate (PLP)-dependent enzyme that utilizes NAD and -adenosylmethionine (SAM) to build the bicyclic alkaloid scaffold, opening the door for biosynthetic studies of NAD-derived natural products.
氧化还原辅因子β-烟酰胺腺嘌呤二核苷酸（NAD）已被揭示可作为生物碱天然产物阿尔特米西定生物合成的一个构件。生物合成途径研究鉴定出一种独特的依赖于焦磷酸吡哆醛（PLP）的酶，该酶利用NAD和S-腺苷甲硫氨酸（SAM）构建双环生物碱骨架，为NAD衍生天然产物的生物合成研究打开了大门。
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