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Candidate drug repurposing for malaria: perspectives for optimising clinical trials.

作者信息

Espinoza J Luis

机构信息

Faculty of Health Sciences, Kanazawa University, Kanazawa, Japan.

Baptist Hospital of Nicaragua, Managua, Nicaragua.

出版信息

Lancet Reg Health Am. 2024 Nov 14;41:100939. doi: 10.1016/j.lana.2024.100939. eCollection 2025 Jan.

DOI:10.1016/j.lana.2024.100939
PMID:39628989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11613157/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e765/11613157/1e44a56de1b2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e765/11613157/1e44a56de1b2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e765/11613157/1e44a56de1b2/gr1.jpg

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本文引用的文献

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Malaria patient spectrum representation in therapeutic clinical trials of uncomplicated malaria: a scoping review of the literature.治疗无并发症疟疾的临床试验中疟疾患者谱的代表性:文献范围综述。
Malar J. 2023 Feb 10;22(1):50. doi: 10.1186/s12936-023-04441-5.
2
Imatinib augments standard malaria combination therapy without added toxicity.伊马替尼可增强标准疟疾联合疗法,且无额外毒性。
J Exp Med. 2021 Oct 4;218(10). doi: 10.1084/jem.20210724. Epub 2021 Aug 26.
3
Should Deep-Sequenced Amplicons Become the New Gold Standard for Analyzing Malaria Drug Clinical Trials?
深度测序扩增子是否应成为分析疟疾药物临床试验的新标准?
Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0043721. doi: 10.1128/AAC.00437-21. Epub 2021 Jul 12.
4
Malaria Resurgence in the Americas: An Underestimated Threat.美洲疟疾卷土重来:一个被低估的威胁。
Pathogens. 2019 Jan 18;8(1):11. doi: 10.3390/pathogens8010011.
5
New leads for drug repurposing against malaria.抗疟药物再利用的新线索。
Drug Discov Today. 2019 Jan;24(1):263-271. doi: 10.1016/j.drudis.2018.08.006. Epub 2018 Aug 9.
6
Inhibition of an Erythrocyte Tyrosine Kinase with Imatinib Prevents Plasmodium falciparum Egress and Terminates Parasitemia.伊马替尼抑制红细胞酪氨酸激酶可阻止恶性疟原虫逸出并终止寄生虫血症。
PLoS One. 2016 Oct 21;11(10):e0164895. doi: 10.1371/journal.pone.0164895. eCollection 2016.
7
Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis.间日疟原虫氯喹耐药的全球范围:一项系统评价和荟萃分析
Lancet Infect Dis. 2014 Oct;14(10):982-91. doi: 10.1016/S1473-3099(14)70855-2. Epub 2014 Sep 8.
8
Experience and challenges from clinical trials with malaria vaccines in Africa.在非洲进行疟疾疫苗临床试验的经验和挑战。
Malar J. 2013 Mar 4;12:86. doi: 10.1186/1475-2875-12-86.