Noiret Aude, Aujard Fabienne, Terrien Jeremy
Unité Mécanismes Adaptatifs et Evolution (MECADEV), UMR 7179, CNRS, Muséum national d'Histoire naturelle, Brunoy, France.
Anim Reprod. 2024 Nov 18;21(4):e20230137. doi: 10.1590/1984-3143-AR2023-0137. eCollection 2024.
Deslorelin is a GnRH agonist used in veterinary medicine to temporarily inhibit reproduction in domestic animals and is sometimes tested in captive species in zoo to control population or tame aggressive behaviours in males. However, some studies have revealed the inefficacy of deslorelin specifically in males, contrary to females that follow a classic long-term inhibition of the reproductive hypothalamic-pituitary axis through sexual steroid negative feedback. We implanted 5 males and 6 females grey mouse lemurs (), long-day breeders that display a complete inhibition of the reproductive system during winter, at the end of the short-day period, a few weeks before the breeding season. Contrary to females, which exhibited a classic inhibitory response to deslorelin, males' testosterone levels increased as well as their testis size, which suggests a sex-specific sensitivity to the negative feedback of sexual steroids before the mating period. We propose that this sex-imbalance is related to the different life-history of males as opposed to females concerning reproductive tasks and behaviour.
地洛瑞林是一种促性腺激素释放激素（GnRH）激动剂，用于兽医学中暂时抑制家畜的繁殖，有时也在动物园的圈养物种中进行测试，以控制种群数量或抑制雄性的攻击行为。然而，一些研究表明，地洛瑞林对雄性尤其无效，这与雌性通过性类固醇负反馈对生殖下丘脑-垂体轴进行经典的长期抑制不同。我们在短日照期结束时，即繁殖季节前几周，给5只雄性和6只雌性灰鼠狐猴（长日照繁殖者，在冬季会完全抑制生殖系统）植入了地洛瑞林。与表现出对地洛瑞林经典抑制反应的雌性不同，雄性的睾酮水平以及睾丸大小都增加了，这表明在交配期之前，雄性对性类固醇负反馈具有性别特异性敏感性。我们认为，这种性别失衡与雄性和雌性在生殖任务和行为方面不同的生活史有关。
