Yuan Jinxiang, Yao Xinyi, Liu Lvye, Zhang Junling
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, People's Republic of China.
Clin Cosmet Investig Dermatol. 2024 Nov 28;17:2725-2731. doi: 10.2147/CCID.S486976. eCollection 2024.
Pemphigus foliaceus (PF) and bullous pemphigoid (BP) are distinct autoimmune bullous skin diseases mediated by autoantibodies targeting adhesion molecules in desmosomes and hemidesmosomes structural proteins in the epidermal-basement membrane zone, respectively. The coexistence of PF and BP is rare. We present the case of a 72-year-old male with clinical and histological features of both PF and BP. Treatment with immunoglobulin (10 g/day for 3 days), intravenous dexamethasone sodium phosphate (5 mg/day for 10 days), oral triamcinolone (30 mg/day for 10 days), and minocycline hydrochloride (20 mg/day for 10 days) resulted in significant improvement. This rare case highlights the importance of accurate diagnosis and effective treatment strategies for the coexistence of PF and BP.
落叶型天疱疮（PF）和大疱性类天疱疮（BP）是两种不同的自身免疫性大疱性皮肤病，分别由针对桥粒黏附分子和表皮-基底膜区半桥粒结构蛋白的自身抗体介导。PF和BP共存的情况很少见。我们报告了一例72岁男性患者，其具有PF和BP的临床及组织学特征。采用免疫球蛋白（10g/天，共3天）、静脉注射地塞米松磷酸钠（5mg/天，共10天）、口服曲安奈德（30mg/天，共10天）和盐酸米诺环素（20mg/天，共10天）进行治疗后，病情显著改善。这一罕见病例凸显了准确诊断以及针对PF和BP共存情况的有效治疗策略的重要性。
