Ishino Yoshizumi
Department of Bioscience and Biotechnology, Graduate school of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 819-0395, Japan.
Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Kanagawa 226-8503, Japan.
Eng Microbiol. 2024 May 28;4(2):100153. doi: 10.1016/j.engmic.2024.100153. eCollection 2024 Jun.
The recent discovery of the CRISPR-Cas-mediated acquired immunity system highlights the fact that our knowledge of phage/virus defense mechanisms encoded in bacterial and archaeal genomes is far from complete. Indeed, new prokaryotic immune systems are now continually being discovered. A recent report described a novel glycosylase that recognizes α-glycosyl-hydroxymethyl cytosin (α-Glu-hmC), a modified base observed in the T4 phage genome, where it produces an abasic site, thereby inhibiting the phage propagation.
CRISPR-Cas介导的获得性免疫系统的最新发现凸显了这样一个事实，即我们对细菌和古菌基因组中编码的噬菌体/病毒防御机制的了解还远远不够完整。事实上，新的原核生物免疫系统现在仍在不断被发现。最近的一份报告描述了一种新型糖基化酶，它能识别α-糖基羟甲基胞嘧啶（α-Glu-hmC），这是在T4噬菌体基因组中观察到的一种修饰碱基，该酶在其中产生一个无碱基位点，从而抑制噬菌体繁殖。
