Nori Harshita, Kaur Harvinder, Singh Surjit, Bhalla Anil Kumar
Department of Pediatrics, Child Growth and Anthropology Unit, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Department of Pediatrics, Allergy and Immunology Unit, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
J Family Med Prim Care. 2024 Oct;13(10):4616-4622. doi: 10.4103/jfmpc.jfmpc_480_24. Epub 2024 Oct 18.
To study the pattern of physical growth and pubertal changes in adolescent girls with Systemic Lupus Erythematosus (SLE).
Weight, height, BMI, waist and hip circumference among 50 adolescent SLE girls (aged 8-17 years) were cross-sectionally studied using standardized techniques and instruments. Breast development stage, presence or absence of pubic and axillary hair and age of attainment of menarche were also noted.
With the advancement of age, weight and height of SLE girls increased but they were lighter and shorter compared to normal Indian peers. 18.4% of study girls were short-statured while only one participant was underweight. As per mid-parental height, 34.3% were predicted to have shorter final heights. BMI demonstrated an inconsistent trend with 12.3% and 9.2% being obese and overweight, respectively. Interestingly, 10.7% of SLE girls were at risk of metabolic syndrome (waist circumference >70 centile). About 50% of study girls had attained menarche (mean age: 13.04 ± 1.38 years). Appearance of pubic and axillary hair occurred around 1 year later than attainment of menarche. 33.80% of study subjects were in prepubertal stage of breast development and rest 66.20% were in advanced stages of breast development. SLE girls who had younger age at diagnosis and longer duration of therapy had significant delay in breast development and attainment of menarche.
SLE girls show delayed growth and pubertal attainments compared to their normal Indian and Western counterparts. The data presented will provide an understanding of the auxological dynamics and pattern of pubertal changes among adolescent girls with SLE living in north-western India.
研究系统性红斑狼疮（SLE）青春期女孩的身体生长模式和青春期变化。
采用标准化技术和仪器，对50名年龄在8至17岁的青春期SLE女孩的体重、身高、体重指数（BMI）、腰围和臀围进行横断面研究。同时记录乳房发育阶段、阴毛和腋毛的有无以及月经初潮年龄。
随着年龄增长，SLE女孩的体重和身高增加，但与正常印度同龄人相比，她们更轻、更矮。18.4%的研究女孩身材矮小，而只有一名参与者体重过轻。根据父母平均身高预测，34.3%的女孩最终身高会更矮。BMI呈现不一致的趋势，分别有12.3%和9.2%的女孩肥胖和超重。有趣的是，10.7%的SLE女孩有代谢综合征风险（腰围>第70百分位数）。约50%的研究女孩已月经初潮（平均年龄：13.04±1.38岁）。阴毛和腋毛出现的时间比月经初潮晚约1年。33.80%的研究对象处于乳房发育的青春期前阶段，其余66.20%处于乳房发育的晚期阶段。诊断时年龄较小且治疗时间较长的SLE女孩在乳房发育和月经初潮方面有明显延迟。
与正常印度和西方同龄人相比，SLE女孩生长和青春期发育延迟。所呈现的数据将有助于了解印度西北部青春期SLE女孩的人体测量学动态和青春期变化模式。
