Mishra Shweta
SGT College of Pharmacy, SGT University, Gurugram, Haryana, India, 122505.
Cent Nerv Syst Agents Med Chem. 2024 Dec 3. doi: 10.2174/0118715249344284241112184703.
Flavonoids have a wide range of neuroprotective effects on the brain, including the capacity to reduce neuroinflammation, shield neurons from harm caused by neurotoxins, and maybe improve memory, learning, and cognitive function. These functions are most likely a result of two similar mechanisms. Inhibiting neurotoxic substance-induced apoptosis and promoting synaptic plasticity and neuronal survival are achieved by first interacting with key protein and lipid kinase signaling pathways in the brain. Second, they have positive effects on the vascular system that alter cerebrovascular blood flow and can result in angiogenesis, neurogenesis, and morphological alterations in neurons. Through these pathways, eating foods high in flavonoids has the potential to avoid or delay age-related impairments in cognitive abilities as well as neurodegeneration. Due to the high level of interest in creating new pharmaceuticals that might improve the cognitive function of the brain, Flavonoids could be important preparatory substances in the development of a new class of brain-improving drugs.
类黄酮对大脑具有广泛的神经保护作用，包括减少神经炎症的能力、保护神经元免受神经毒素造成的损害，以及可能改善记忆、学习和认知功能。这些功能很可能是由两种相似的机制导致的。通过首先与大脑中的关键蛋白质和脂质激酶信号通路相互作用，可抑制神经毒性物质诱导的细胞凋亡，并促进突触可塑性和神经元存活。其次，它们对血管系统有积极影响，可改变脑血管血流量，并可能导致血管生成、神经发生以及神经元的形态改变。通过这些途径，食用富含类黄酮的食物有可能避免或延缓与年龄相关的认知能力损害以及神经退行性变。由于人们对开发可能改善大脑认知功能的新药物兴趣浓厚，类黄酮可能是新型脑改善药物开发中的重要预备物质。
