Puyana Carolina, Ilyas Muneeb, Weiss Eduardo, Saleeby Eli
J Drugs Dermatol. 2024 Dec 1;23(12):1094-1099. doi: 10.36849/jdd.7898.
Lentigo maligna (LM), a type of melanoma in situ (MIS), usually develops on sun-damaged skin in the elderly. If left untreated, it may advance to the point of dermal invasion, developing into lentigo maligna melanoma (LMM). While surgeons have achieved robust clinical outcomes for LM treated with Mohs micrographic surgery (MMS), performing this treatment for LMM remains controversial and is not standard amongst all Mohs surgeons.
We examined survival outcomes in LM/LMM cases treated with MMS and wide local excision (WLE).
Data from the National Cancer Institute Surveillance, Epidemiology, and End Results (NCI SEER) program, collected from 2000-2019, was retrospectively analyzed. Patients with microscopically confirmed diagnosis of LM/LMM who received surgical treatment with MMS or WLE were included. The effect of different surgery types on melanoma survival was evaluated.
A total of 22,852 LM/LMM cases performed during the years 2000-2019 were considered for analysis. There were no significant differences in disease-specific survival comparing WLE to MMS.
Our research hints at the utility of MMS for LM/LMM. We encourage practitioners to consider MMS for the management LM/LMM when appropriate. J Drugs Dermatol. 2024;23(12):1094-1099. doi:10.36849/JDD.7898.
恶性雀斑样痣（LM）是一种原位黑色素瘤（MIS），通常发生于老年人受阳光损伤的皮肤。若不治疗，其可能进展至真皮浸润阶段，发展为恶性雀斑样痣黑色素瘤（LMM）。虽然外科医生采用莫氏显微外科手术（MMS）治疗LM已取得了良好的临床效果，但对于LMM进行这种治疗仍存在争议，且并非所有莫氏外科医生的标准治疗方法。
我们研究了采用MMS和广泛局部切除（WLE）治疗的LM/LMM病例的生存结果。
对2000年至2019年期间从美国国立癌症研究所监测、流行病学和最终结果（NCI SEER）项目收集的数据进行回顾性分析。纳入经显微镜确诊为LM/LMM且接受MMS或WLE手术治疗的患者。评估不同手术类型对黑色素瘤生存的影响。
共纳入2000年至2019年期间进行的22852例LM/LMM病例进行分析。比较WLE和MMS，疾病特异性生存率无显著差异。
我们的研究提示了MMS对LM/LMM的治疗价值。我们鼓励从业者在适当的时候考虑采用MMS治疗LM/LMM。《药物皮肤病学杂志》。2024年；23(12):1094-1099。doi:10.36849/JDD.7898。
