Sahin Refaettin, Tanacan Atakan, Serbetci Hakki, Ozkavak Osman Onur, Haksever Murat, Basarir Mehmet Utku, Kara Ozgur, Sahin Dilek
Turkish Ministry of Health Ankara City Hospital, Department of Obstetrics and Gynecology, Division of Perinatology - Ankara, Turkey.
University of Health Sciences, Turkish Ministry of Health Ankara City Hospital, Department of Obstetrics and Gynecology, Division of Perinatology - Ankara, Turkey.
Rev Assoc Med Bras (1992). 2024 Dec 2;70(11):e20240938. doi: 10.1590/1806-9282.20240938. eCollection 2024.
The objective of this study was to evaluate the descriptive outcomes of 38 prenatally suspected clubfoot cases.
This is a retrospective cohort study conducted in Ankara Bilkent City Hospital's perinatology clinic. All consecutive cases with the diagnosis of fetal clubfoot between 2020 and 2023 were included. Multiple pregnancies and skeletal dysplasias were excluded from the study. Demographic features, prenatal ultrasound findings, prenatal screening test results, invasive diagnostic test results, clinical approaches, short-term and long-term postnatal outcomes, and treatment types of clubfoot were reported.
There were a total of 38 prenatally diagnosed clubfoot cases noted during the study period. The mean gestational age at diagnosis was 15.3±1.4 weeks. Prenatal ultrasound screening noted bilateral clubfoot in 16 (42.1%) cases and unilateral clubfoot in 22 (57.8%) cases. Clubfoot was isolated in 7 (18.4%) cases, and additional anomalies were present in 31 (81.6%) cases. The gender of the fetuses was 26 (68.4%) males and 12 (31.6%) females. The prenatal noninvasive screening test was high risk in 7 (18.4%) patients and low risk in 16 (42.1%) patients. As a result of amniocentesis performed in 16 (42.1%) patients, abnormal karyotypes were detected in 2 patients (trisomy 18, 22q11.2 del). Six pregnancies were terminated before 24 weeks, and 27 pregnancies resulted in live birth at an average of 37.8±2.5 weeks. The diagnosis was correct in 84.2% of the cases, and 84.6% of the pregnancies resulted in live births.
The outcomes of congenital clubfoot are generally favorable, especially in isolated cases.
本研究的目的是评估38例产前疑似马蹄内翻足病例的描述性结果。
这是一项在安卡拉比尔肯特市医院围产医学诊所进行的回顾性队列研究。纳入了2020年至2023年间所有连续诊断为胎儿马蹄内翻足的病例。多胎妊娠和骨骼发育异常被排除在研究之外。报告了人口统计学特征、产前超声检查结果、产前筛查试验结果、侵入性诊断试验结果、临床处理方法、产后短期和长期结果以及马蹄内翻足的治疗类型。
研究期间共记录到38例产前诊断为马蹄内翻足的病例。诊断时的平均孕周为15.3±1.4周。产前超声筛查发现16例（42.1%）为双侧马蹄内翻足，22例（57.8%）为单侧马蹄内翻足。7例（18.4%）为单纯马蹄内翻足，31例（81.6%）伴有其他异常。胎儿性别为男26例（68.4%），女12例（31.6%）。7例（18.4%）患者的产前无创筛查试验为高风险，16例（42.1%）患者为低风险。16例（42.1%）患者进行了羊水穿刺，2例患者检测到异常核型（18三体、22q11.2缺失）。6例妊娠在24周前终止，27例妊娠平均在37.8±2.5周时活产。84.2%的病例诊断正确，84.6%的妊娠活产。
先天性马蹄内翻足的结果总体良好，尤其是单纯病例。
