Doepke Amos, Streicher Robert P, Shaw Peter B, N Andrews Ronnee, Farwick Dawn R, Westbrook Emily G, Roberts Jennifer L, O'Connor Paula F, Stastny Angela L, Kulkarni Pramod S
Health Effects Laboratory Division, Chemical and Biological Monitoring Branch, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Department of Science and Health, Clermont College, University of Cincinnati, Batavia, Ohio.
J Occup Environ Hyg. 2025 Feb;22(2):110-122. doi: 10.1080/15459624.2024.2423749. Epub 2024 Dec 4.
A significant portion of the work of developing and validating methods for volatile organic compound (VOC) sampling in workplace atmospheres involves the use of laboratory-generated atmospheres. The sample variability was evaluated from the dynamic atmosphere generation system used for VOC atmosphere generation and sampling. Characterization of the bias and variability of samples was done for a variety of atmospheres containing neat n-heptane and mixtures of VOCs sampled on activated coconut shell charcoal. Estimates of sampling variability ranged from 2% for neat n-heptane to 12% for a component in the 10 VOC mix. Sample variability increased for lower concentration samples and for mixtures of VOCs compared to single component atmospheres. This study can serve as a baseline for future atmosphere sampling experiments evaluating performance at lower concentrations and mixed VOC environments.
开发和验证工作场所大气中挥发性有机化合物（VOC）采样方法的很大一部分工作涉及使用实验室生成的大气。通过用于VOC大气生成和采样的动态大气生成系统评估了样品变异性。针对在活性椰壳炭上采样的各种含有纯正庚烷和VOC混合物的大气，对样品的偏差和变异性进行了表征。采样变异性的估计范围从纯正庚烷的2%到10种VOC混合物中一种成分的12%。与单一组分大气相比，低浓度样品和VOC混合物的样品变异性增加。这项研究可以作为未来在较低浓度和混合VOC环境下评估性能的大气采样实验的基线。
