Hatanaka Mai, Hara Kazuhiro, Ohba Chisato, Suzuki Masashi, Ogura Aya, Kawabata Kazuya, Ito Yoshinori, Tada Tomohiro, Fujita Naotoshi, Mori Daisuke, Maesawa Satoshi, Kato Katsuhiko, Katsuno Masahisa
Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho Showa-ku, Nagoya 466-8550, Japan.
Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho Showa-ku, Nagoya 466-8550, Japan; Department of Clinical Laboratory, Nagoya University Hostpital, 65 Tsurumai-cho Showa-ku, Nagoya 466-8550, Japan.
J Neurol Sci. 2025 Jan 15;468:123331. doi: 10.1016/j.jns.2024.123331. Epub 2024 Nov 26.
Degeneration of the nigrostriatal system occurs in multiple system atrophy (MSA) and Parkinson's disease (PD) via distinct pathological mechanisms. Here, we investigated nigrostriatal degeneration in MSA and PD by combining a newly developed method for evaluating the regional accumulation of dopamine transporter single-photon emission computed tomography (DAT SPECT) and individual voxel-based morphometry adjusting covariates (iVAC). We recruited 17 MSA patients and 13 PD patients, and compared their clinical and imaging indices. All patients underwent DAT SPECT and head three-dimensional T1-weighted magnetic resonance imaging. We calculated the specific binding ratio (SBR) of the putamen and caudate separately using a region-based method, and evaluated the association between the SBR and iVAC Z-score. SBR values of the putamen and caudate were lower in the PD group than in the MSA group (p < 0.001 for both). The MSA and PD groups had lower SBR values in the putamen than in the caudate (p < 0.05 and p < 0.001, respectively). We found a negative correlation between the putamen SBR and iVAC Z-score in MSA (p < 0.001, r = -0.775), but such a correlation was not detected in PD. For the caudate, there was no correlation between the SBR and iVAC Z-score in MSA and PD. Our results indicate different mechanisms of reduced uptake of DATs in MSA and PD. The association between the striatal SBR and iVAC Z-score suggests parallel degeneration in the substantia nigra and striatum in MSA.
黑质纹状体系统的退化在多系统萎缩（MSA）和帕金森病（PD）中通过不同的病理机制发生。在此，我们通过结合一种新开发的评估多巴胺转运体单光子发射计算机断层扫描（DAT SPECT）区域积聚的方法和基于个体体素形态学调整协变量（iVAC）来研究MSA和PD中的黑质纹状体退化。我们招募了17例MSA患者和13例PD患者，并比较了他们的临床和影像学指标。所有患者均接受了DAT SPECT和头部三维T1加权磁共振成像。我们使用基于区域的方法分别计算壳核和尾状核的特异性结合率（SBR），并评估SBR与iVAC Z评分之间的关联。PD组壳核和尾状核的SBR值低于MSA组（两者均p < 0.001）。MSA组和PD组壳核的SBR值低于尾状核（分别为p < 0.05和p < 0.001）。我们发现MSA中壳核SBR与iVAC Z评分之间存在负相关（p < 0.001，r = -0.775），但在PD中未检测到这种相关性。对于尾状核，MSA和PD中SBR与iVAC Z评分之间均无相关性。我们的结果表明MSA和PD中DAT摄取减少的机制不同。纹状体SBR与iVAC Z评分之间的关联表明MSA中黑质和纹状体存在平行退化。
