Zhang Yanfei, Liu Qingxuan, Xie Hongxin, Zhang Wei, Lin Xiaoying, Zhang Huifeng, Yu Huan, Ma Yinghui, Zhang Chuang, Geng Hao, Shi Nianqiu, Cui Liwei, Li Bai, Li Yu-Feng
Jilin Medical University, Jilin 132013, Jilin, China.
CAS-HKU Joint Laboratory of Metallomics on Health and Environment, & CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, & Beijing Metallomics Facility, & National Consortium for Excellence in Metallomics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Sci Total Environ. 2024 Dec 20;957:177850. doi: 10.1016/j.scitotenv.2024.177850. Epub 2024 Dec 3.
Methylmercury (MeHg) can cause devastating neurotoxicity in animals and human beings. Gut microbiota dysbiosis has been found in MeHg-poisoned animals. Fecal microbiota transplantation (FMT) has been shown to improve clinical outcomes in a variety of diseases such as epilepsy, amyotrophic lateral sclerosis (ALS) and autism. The aim of this study was to investigate the effects of FMT on MeHg-poisoned rats. FMT treatment was applied to MeHg-poisoned rats for 14 days. The neurobehavior, weight changes, dopamine (DA), the total Hg and MeHg level were evaluated. Besides, the gut microbiota and metabolites change in feces were also checked. It was found that FMT helped weight gain, alleviated the neurological disorders, enhanced fecal mercury excretion and MeHg demethylation, reconstructed gut microbiome and promoted the production of gut-brain axis related-metabolites in MeHg-poisoned rats. This study elaborates on the therapeutic efficacy of FMT in treating of MeHg-poisoned rats, which sheds lights on the treatment of neurological diseases like Minamata Disease and even Parkinson's Disease.
甲基汞（MeHg）可在动物和人类中引发毁灭性的神经毒性。在甲基汞中毒的动物中已发现肠道微生物群失调。粪便微生物群移植（FMT）已被证明可改善多种疾病的临床结局，如癫痫、肌萎缩侧索硬化症（ALS）和自闭症。本研究的目的是探讨FMT对甲基汞中毒大鼠的影响。对甲基汞中毒大鼠进行了14天的FMT治疗。评估了神经行为、体重变化、多巴胺（DA）、总汞和甲基汞水平。此外，还检查了粪便中肠道微生物群和代谢产物的变化。结果发现，FMT有助于甲基汞中毒大鼠体重增加，缓解神经紊乱，增强粪便汞排泄和甲基汞去甲基化，重建肠道微生物群，并促进肠道-脑轴相关代谢产物的产生。本研究阐述了FMT治疗甲基汞中毒大鼠的疗效，为水俣病甚至帕金森病等神经疾病的治疗提供了线索。
