Zhang Zhanrui, Liu Hongyu, Chen Jun
Department of Thoracic Surgery, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832003, China.
Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
Zhongguo Fei Ai Za Zhi. 2024 Oct 20;27(10):785-791. doi: 10.3779/j.issn.1009-3419.2024.102.34.
Ferroptosis is a recently discovered form of cell death that is distinct from apoptosis, characterized primarily by the accumulation of intracellular iron and increased levels of lipid peroxidation. Resistance of tumor cells to ferroptosis can promote tumorigenesis and tumor progression. Various compounds can influence tumor development by triggering ferroptosis. Ferroptosis involves complex regulatory mechanisms, with mitochondria serving as both an iron storage and metabolic center, playing a crucial regulatory role in ferroptosis. This review discusses ferroptosis and its three stages and the role of ferroptosis in tumorigenesis, progression, and treatment, as well as the regulatory mechanisms of mitochondria in ferroptosis. .
铁死亡是一种最近发现的细胞死亡形式，与细胞凋亡不同，其主要特征是细胞内铁的积累和脂质过氧化水平的升高。肿瘤细胞对铁死亡的抗性可促进肿瘤发生和肿瘤进展。各种化合物可通过引发铁死亡来影响肿瘤发展。铁死亡涉及复杂的调控机制，线粒体既是铁储存中心又是代谢中心，在铁死亡中起关键调控作用。本文综述了铁死亡及其三个阶段、铁死亡在肿瘤发生、进展和治疗中的作用，以及线粒体在铁死亡中的调控机制。
