Yu Dahai, Fu Hang, Zhao Zhanzheng, Pickering Karen, Baker John, Cutfield Richard, Orr-Walker Brandon J, Sundborn Gerhard, Cai Yamei, Wang Zheng, Wang Chengzeng, Simmons David
Henan Key Laboratory of Chronic Disease Prevention and Therapy & Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzholu, Henan, China.
BMJ Open Diabetes Res Care. 2024 Dec 4;12(6):e004210. doi: 10.1136/bmjdrc-2024-004210.
To evaluate the long-term risk of developing type 2 diabetes (T2D) among women with a history of gestational diabetes mellitus (GDM) compared with those with impaired glucose tolerance (IGT).
Using data from a primary care dataset linked with multiple health registries, this longitudinal study analyzed demographics, clinical data, and lifestyle factors of women diagnosed with GDM or IGT, assessing T2D incidence over 25 years, using Cox regression models.
Women with GDM, especially those over 35 years of Māori ethnicity, or socioeconomic deprivation, exhibited an elevated risk of T2D compared with those with IGT. The first 5 years post partum emerged as a critical window for intervention.
This study underscores the importance of early, targeted post-GDM interventions to mitigate T2D risk. It highlights the necessity of personalized post-GDM interventions to reduce T2D incidence which consider age, ethnicity, and socioeconomic status to maximize effectiveness.
评估有妊娠期糖尿病（GDM）病史的女性与糖耐量受损（IGT）女性相比患2型糖尿病（T2D）的长期风险。
利用与多个健康登记处相关联的初级保健数据集的数据，这项纵向研究分析了被诊断为GDM或IGT的女性的人口统计学、临床数据和生活方式因素，使用Cox回归模型评估25年间的T2D发病率。
与IGT女性相比，GDM女性，尤其是35岁以上的毛利族或社会经济贫困女性，患T2D的风险更高。产后的前5年是干预的关键窗口期。
本研究强调了早期、有针对性的GDM后干预对降低T2D风险的重要性。它突出了个性化GDM后干预以降低T2D发病率的必要性，这种干预要考虑年龄、种族和社会经济地位以最大化有效性。
