Umlauff Lisa, Kenfield Stacey A, Newton Robert U, Hart Nicolas H, Saad Fred, Courneya Kerry S, Greenwood Rosemary, Bloch Wilhelm, Schumann Moritz
Department for Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany.
Department of Urology and Epidemiology & Biostatistics, University of California, San Francisco, California, USA.
Cancer Med. 2024 Dec;13(23):e70261. doi: 10.1002/cam4.70261.
This study compared the physical activity level of men with metastatic prostate cancer at baseline of the multicentre INTERVAL-GAP4 trial to the American Cancer Society guidelines and examined associations with physical fitness.
A total of 140 men on androgen deprivation therapy (ADT) were included in this cross-sectional analysis of baseline data from the INTERVAL-GAP4 trial. Exclusion criteria included a maximum of 1 h of vigorous aerobic exercise or one structured resistance exercise session per week but no restrictions on habitual physical activity. Moderate-to-vigorous physical activity (MVPA) was assessed using a modified Godin-Shephard Leisure-Time Physical Activity Questionnaire. Physical fitness measurements included peak oxygen consumption (VOpeak), maximal power output (W), 400 m walk time, one-repetition maximum (1RM) of leg extension, leg press, chest press and seated row, and handgrip strength. Quantile regression was used to analyse associations of MVPA with physical fitness outcomes at the 25, 50 and 75 percentiles of the physical fitness distributions.
Total self-reported MVPA was 60 (IQR: 0, 180) min per week, with 29% meeting the aerobic physical activity guidelines. There was a statistically significant association of higher MVPA with higher relative VOpeak at the 25 (β = 0.53, p = 0.020) and 75 percentiles (β = 0.66, p = 0.001), relative W at the 25 (β = 0.05, p = 0.003), 50 (β = 0.05, p = 0.009) and 75 percentiles (β = 0.07, p = 0.004) and reduced 400 m walk time at the 75 percentile (β = -4.26, p = 0.023), with β corresponding to the change in the dependent variable for each one-hour increase in weekly MVPA.
Few men recruited to the INTERVAL-GAP4 trial were meeting aerobic physical activity guidelines at baseline. Higher MVPA was associated with better aerobic capacity and walking performance but not maximal strength in men with metastatic prostate cancer on ADT.
ClinicalTrials.gov: NCT02730338; German Clinical Trials Register: DRKS00010310.
本研究将多中心INTERVAL - GAP4试验基线时转移性前列腺癌男性的身体活动水平与美国癌症协会指南进行了比较，并研究了其与身体素质的关联。
本横断面分析纳入了140名接受雄激素剥夺治疗（ADT）的男性，数据来自INTERVAL - GAP4试验的基线。排除标准包括每周最多进行1小时的剧烈有氧运动或一次有组织的抗阻训练课程，但对习惯性身体活动无限制。使用改良的戈丁 - 谢泼德休闲时间身体活动问卷评估中度至剧烈身体活动（MVPA）。身体素质测量包括峰值耗氧量（VOpeak）、最大功率输出（W）、400米步行时间、腿部伸展、腿举、卧推和坐姿划船的一次重复最大值（1RM）以及握力。使用分位数回归分析MVPA与身体素质分布的第25、50和75百分位数处的身体素质结果之间的关联。
自我报告的每周总MVPA为60（四分位距：0，180）分钟，29%的人符合有氧身体活动指南。在第25百分位数（β = 0.53，p = 0.020）和第75百分位数（β = 0.66，p = 0.001）时，较高的MVPA与较高的相对VOpeak存在统计学显著关联；在第25百分位数（β = 0.05，p = 0.003）、第50百分位数（β = 0.05，p = 0.009）和第75百分位数（β = 0.07，p = 0.004）时，与较高的相对W存在统计学显著关联；在第75百分位数时，与400米步行时间缩短存在统计学显著关联（β = -4.26，p = 0.023），其中β对应每周MVPA每增加一小时时因变量的变化。
纳入INTERVAL - GAP4试验的男性在基线时很少有人符合有氧身体活动指南。较高的MVPA与转移性前列腺癌接受ADT治疗的男性更好的有氧能力和步行表现相关，但与最大力量无关。
ClinicalTrials.gov：NCT02730338；德国临床试验注册中心：DRKS00010310。
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