一项针对前列腺癌男性的运动训练随机对照试验的健康状况结果：ENGAGE研究
Fitness outcomes from a randomised controlled trial of exercise training for men with prostate cancer: the ENGAGE study.
作者信息
Gaskin Cadeyrn J, Fraser Steve F, Owen Patrick J, Craike Melinda, Orellana Liliana, Livingston Patricia M
机构信息
Faculty of Health, Deakin University, Locked Bag 20001, Geelong, Victoria, 3220, Australia.
Institute for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, Australia.
出版信息
J Cancer Surviv. 2016 Dec;10(6):972-980. doi: 10.1007/s11764-016-0543-6. Epub 2016 Apr 20.
PURPOSE
The main purpose of this study was to investigate the effects of a 12-week, clinician-referred, community-based exercise training program with supervised and unsupervised sessions for men with prostate cancer. The secondary purpose was to determine whether androgen deprivation therapy (ADT) modified responses to exercise training.
METHODS
Secondary analysis was undertaken on data from a multicentre cluster randomised controlled trial in which 15 clinicians were randomly assigned to refer eligible patients to an exercise training intervention (n = 8) or to provide usual care (n = 7). Data from 119 patients (intervention n = 53, control n = 66) were available for this analysis. Outcome measures included fitness and physical function, anthropometrics, resting heart rate, and blood pressure.
RESULTS
Compared to the control condition, men in the intervention significantly improved their 6-min walk distance (M = 49.98 m, p = 0.001), leg strength (M = 21.82 kg, p = 0.001), chest strength (M = 6.91 kg, p = 0.001), 30-s sit-to-stand result (M = 3.38 reps, p = 0.001), and reach distance (M = 4.8 cm, p = 0.024). A significant difference (unadjusted for multiplicity) in favour of men in the intervention was also found for resting heart rate (M = -3.76 beats/min, p = 0.034). ADT did not modify responses to exercise training.
CONCLUSIONS
Men with prostate cancer who act upon clinician referrals to community-based exercise training programs can improve their strength, physical functioning, and, potentially, cardiovascular health, irrespective of whether or not they are treated with ADT.
IMPLICATIONS FOR CANCER SURVIVORS
Clinicians should inform men with prostate cancer about the benefits of exercise and refer them to appropriately qualified exercise practitioners and suitable community-based programs.
TRIAL REGISTRATION
Australia and New Zealand Clinical Trials Register (ANZCTR): ACTRN12610000609055.
目的
本研究的主要目的是调查一项为期12周、由临床医生推荐、基于社区的运动训练计划对前列腺癌男性患者的影响，该计划包括有监督和无监督的训练课程。次要目的是确定雄激素剥夺疗法（ADT）是否会改变对运动训练的反应。
方法
对一项多中心整群随机对照试验的数据进行二次分析，在该试验中，15名临床医生被随机分配，将符合条件的患者转介至运动训练干预组（n = 8）或提供常规护理（n = 7）。本分析采用了119名患者的数据（干预组n = 53，对照组n = 66）。结局指标包括体能和身体功能、人体测量学指标、静息心率和血压。
结果
与对照组相比，干预组男性的6分钟步行距离（M = 49.98米，p = 0.001）、腿部力量（M = 21.82千克，p = 0.001）、胸部力量（M = 6.91千克，p = 0.001）、30秒坐立次数（M = 3.38次，p = 0.001）和伸展距离（M = 4.8厘米，p = 0.024）均有显著改善。静息心率方面也发现干预组男性有显著差异（未进行多重校正）（M = -3.76次/分钟，p = 0.034）。ADT并未改变对运动训练的反应。
结论
听从临床医生建议参加基于社区的运动训练计划的前列腺癌男性患者，无论是否接受ADT治疗，其力量、身体功能以及潜在的心血管健康状况都能得到改善。
对癌症幸存者的启示
临床医生应告知前列腺癌男性患者运动的益处，并将他们转介给具备资质的运动从业者和合适的社区运动计划。
试验注册
澳大利亚和新西兰临床试验注册中心（ANZCTR）：ACTRN12610000609055。
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