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Transcutaneous auricular vagus nerve stimulation might reduce fear memory in fear-conditioned mice through an anti-neuroinflammatory mechanism.

作者信息

Du Yingjie, Zhang Yue, Bai Yafan, Liu Min, Zhang Congya, Chen Yimeng, Li Shaoyuan, Rong Peijing, Wang Guyan

机构信息

Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.

出版信息

Chin Med J (Engl). 2025 Jan 20;138(2):237-239. doi: 10.1097/CM9.0000000000003404. Epub 2024 Dec 5.

DOI:10.1097/CM9.0000000000003404
PMID:39632585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11745844/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5224/11745844/764c02f34d75/cm9-138-237-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5224/11745844/764c02f34d75/cm9-138-237-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5224/11745844/764c02f34d75/cm9-138-237-g001.jpg

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Transcutaneous auricular vagus nerve stimulation might reduce fear memory in fear-conditioned mice through an anti-neuroinflammatory mechanism.经皮耳迷走神经刺激可能通过抗神经炎症机制减少恐惧条件化小鼠的恐惧记忆。
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[The effect of transcutaneous auricular vagus nerve stimulation on fear memory and spleen inflammatory response in fear-conditioned mice].经皮耳迷走神经刺激对恐惧条件化小鼠恐惧记忆及脾脏炎症反应的影响
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本文引用的文献

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Understanding Mental Health Needs and Gathering Feedback on Transcutaneous Auricular Vagus Nerve Stimulation as a Potential PTSD Treatment among 9/11 Responders Living with PTSD Symptoms 20 Years Later: A Qualitative Approach.理解心理健康需求，并就经皮耳迷走神经刺激作为一种潜在的 PTSD 治疗方法在 9/11 后幸存 PTSD 症状 20 年后的反应者中的应用收集反馈：一种定性方法。
Int J Environ Res Public Health. 2022 Apr 16;19(8):4847. doi: 10.3390/ijerph19084847.
2
Changes in the Serum Levels of Cytokines: IL-1β, IL-4, IL-8 and IL-10 in Depression with and without Posttraumatic Stress Disorder.伴有和不伴有创伤后应激障碍的抑郁症患者血清细胞因子水平的变化：白细胞介素-1β、白细胞介素-4、白细胞介素-8和白细胞介素-10
Brain Sci. 2022 Mar 14;12(3):387. doi: 10.3390/brainsci12030387.
3
Mechanisms underlying antidepressant effect of transcutaneous auricular vagus nerve stimulation on CUMS model rats based on hippocampal α7nAchR/NF-κB signal pathway.基于海马体 α7nAchR/NF-κB 信号通路探讨经皮耳迷走神经刺激对 CUMS 模型大鼠抗抑郁作用的机制。
J Neuroinflammation. 2021 Dec 17;18(1):291. doi: 10.1186/s12974-021-02341-6.
4
Post-Traumatic Stress Disorder.创伤后应激障碍
N Engl J Med. 2017 Jun 22;376(25):2459-2469. doi: 10.1056/NEJMra1612499.
5
Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression.创伤后应激障碍中的炎症标志物：系统评价、荟萃分析和元回归分析
Lancet Psychiatry. 2015 Nov;2(11):1002-12. doi: 10.1016/S2215-0366(15)00309-0.