Cheng Lei, Yan Juntao, Shi Wenting, Zhang Jing, Dong Qingjun, Hu Yiren, Zhou Zhongyan, Ye Qing
Department of Tuina, Longhua Hospital Shanghai University of Traditional Chinese Medicine, NO.725, South Wanping Road, Xuhui District, Shanghai, 200032, China.
Department of Tuina, Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, NO.110, Ganhe Road, Hongkou District, Shanghai, 200437, China.
Sci Rep. 2024 Dec 4;14(1):30271. doi: 10.1038/s41598-024-81787-z.
This study aimed to explore the causal relationships between multiple blood amino acids (BAAs) and the Parkinson's disease (PD). We downloaded genome-wide association study (GWAS) data for BAAs and PD from the OpenGWAS database, screened single nucleotide polymorphisms (SNPs) from the data, and evaluated the causal relationship between BAA levels and PD using the inverse variance weighted (IVW) method. The sensitivity analysis was also conducted. After SNP screening, three amino acid indicators were identified: met-a-308 (phenylalanine), met-a-584 (X-12100 hydroxytryptophan), and met-a-337 (5-hydroxyproline), which showed significant causal relationship with the occurrence of PD. There was no significant heterogeneity or horizontal pleiotropy, and the results were stable. The multivariate MR analysis showed that the mediating effects generated by the introduction of multiple variables were not significant. In conclusion, phenylalanine, X-12,100 hydroxytryptophan, and 5-hydroxyproline have a causal relationship with the occurrence of PD and may be potential early screening biomarkers and blocking targets.
本研究旨在探讨多种血液氨基酸（BAA）与帕金森病（PD）之间的因果关系。我们从OpenGWAS数据库下载了BAA和PD的全基因组关联研究（GWAS）数据，从数据中筛选单核苷酸多态性（SNP），并使用逆方差加权（IVW）方法评估BAA水平与PD之间的因果关系。还进行了敏感性分析。经过SNP筛选，确定了三个氨基酸指标：met-a-308（苯丙氨酸）、met-a-584（X-12100羟色氨酸）和met-a-337（5-羟脯氨酸），它们与PD的发生存在显著因果关系。不存在显著的异质性或水平多效性，结果稳定。多变量MR分析表明，引入多个变量产生的中介效应不显著。总之，苯丙氨酸、X-12,100羟色氨酸和5-羟脯氨酸与PD的发生存在因果关系，可能是潜在的早期筛查生物标志物和阻断靶点。
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