Miettinen Heli, Lohela Jesse, Moradi Sadegh, Inget Kalle, Nikkinen Juha, Myllylä Teemu, Karhula Sakari S, Korhonen Vesa
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.
Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland.
Ann Biomed Eng. 2025 Mar;53(3):673-682. doi: 10.1007/s10439-024-03663-1. Epub 2024 Dec 4.
Effects of clinical radiotherapy are often studied between or after irradiations. The current study's aim was to monitor an immediate irradiation response in cerebral water and hemodynamics in patients treated with whole brain radiotherapy (WBRT) and to assess the response's individuality.
We used functional near-infrared spectroscopy (fNIRS) to monitor changes in cerebral water, oxyhemoglobin (HbO), and deoxyhemoglobin (HbR) during the irradiation of 31 patients (age 69.3 ± 12.5 years, 16 females) receiving WBRT. The radiation dose delivered to a patient during a single measurement was 4 Gy (total dose of 20 Gy in five fractions) for most patients and 3 Gy (total dose of 30 Gy in ten fractions) for three patients.
106 patient recordings were analyzed. They showed an immediate irradiation induced increase in HbO and HbR, and decrease in cerebral water content (P < .001) as soon as 5 s after the start of irradiation. The radiation dose, age, and gender affected recorded signals. A smaller dose resulted in a steeper change in HbR (P < .01), but larger total change in HbO (P < .01). Younger age was associated with a more significant decrease in the water signal (P < .05). In contrast, female gender was associated with a greater total increase in HbO (P < .01) and HbR (P < .001) signals.
There is an immediate cerebral water and hemodynamic response to irradiation and this response shows dependency on the radiation dose, age, and gender. Better understanding about the immediate radiation response may help improve the patient outcome in clinical radiotherapy.
临床放疗效果通常在照射期间或照射后进行研究。本研究的目的是监测接受全脑放疗（WBRT）患者大脑水含量和血流动力学的即时照射反应，并评估反应的个体差异。
我们使用功能近红外光谱（fNIRS）监测31例接受WBRT患者（年龄69.3±12.5岁，16例女性）照射期间大脑水含量、氧合血红蛋白（HbO）和脱氧血红蛋白（HbR）的变化。大多数患者单次测量时给予的辐射剂量为4 Gy（分5次给予，总剂量20 Gy），3例患者为3 Gy（分10次给予，总剂量30 Gy）。
分析了106例患者的记录。结果显示，照射开始后5秒，照射立即导致HbO和HbR增加，大脑含水量降低（P <.001）。辐射剂量、年龄和性别影响记录信号。较小剂量导致HbR变化更陡峭（P <.01），但HbO总变化更大（P <.01）。年龄较小与水信号下降更显著相关（P <.05）。相比之下，女性性别与HbO（P <.01）和HbR（P <.001）信号的总增加更大相关。
照射后大脑水含量和血流动力学有即时反应，且这种反应显示出对辐射剂量、年龄和性别的依赖性。更好地了解即时辐射反应可能有助于改善临床放疗的患者预后。
