Bhattacharya Bikramjit, Bhattacharya Shreshtha, Khatun Srinjana, Bhaktham Namitha A, Maneesha M, Subathra Devi C
School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.
Protein J. 2025 Feb;44(1):35-47. doi: 10.1007/s10930-024-10242-9. Epub 2024 Dec 4.
The emergence of multi-drug-resistant pathogens and the decrease in the discovery of newer antibiotics have led to a quest for novel alternatives. Recently, wasp venom has spiked interest due to the presence of various active compounds, showcasing a diverse range of therapeutic effects. Wasps are creatures of the Hymenoptera order, and their venom chemically comprises antimicrobial peptides such as Anoplin, Mastoparan, Polybia-CP, Polydim-I, and Polybia MP1 that play a significant role in the biological effects of the venom. AMPs belong to the family of cationic peptides with α-helical structure, which exhibits a diversity of structural motifs and are crucial for innate immunity and defence in these creatures. These peptides demonstrate not only antimicrobial properties but also a wide range of other biological activities like anti-biofilm and anti-inflammatory, linked to their varying capacity to interact with biological membranes. Although wasp venom has the potential to be a cutting-edge natural source for the creation of new drugs, its usage is still restricted due to its availability and the lack of sophisticated methods for synthesizing its therapeutic components. Therefore, this review article provides insights about the therapeutic use of the wasp venom peptides against the antimicrobial-resistant pathogens, as well as its constraints and opportunities for future pharmacological development.
多重耐药病原体的出现以及新型抗生素发现数量的减少，引发了人们对新型替代物的探索。最近，黄蜂毒液因其含有多种活性化合物而引起了人们的兴趣，展现出多样的治疗效果。黄蜂属于膜翅目昆虫，其毒液在化学组成上包含抗菌肽，如无刺蜂素、马斯托帕兰、多比亚 - CP、多聚二甲基硅氧烷 - I和多比亚MP1，这些抗菌肽在毒液的生物学效应中发挥着重要作用。抗菌肽属于具有α - 螺旋结构的阳离子肽家族，其结构基序多样，对这些生物的固有免疫和防御至关重要。这些肽不仅具有抗菌特性，还具有广泛的其他生物活性，如抗生物膜和抗炎活性，这与其与生物膜相互作用的不同能力有关。尽管黄蜂毒液有可能成为开发新药的前沿天然来源，但其使用仍受到限制，原因在于其可获得性以及缺乏合成其治疗成分的复杂方法。因此，这篇综述文章提供了有关黄蜂毒液肽针对耐抗菌病原体的治疗用途的见解，以及其在未来药理学发展中的限制和机遇。
