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PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma.

作者信息

Weng Yue, Yan Xiangyu, Chen Biying, Bian Zhouliang, Ge Yunhui, Lu Hong, He Shufang, Wu Jian, Chen Yong, Lei Ming, Zhang Yanjie

机构信息

Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China.

State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

出版信息

Genes Dis. 2024 May 7;12(2):101319. doi: 10.1016/j.gendis.2024.101319. eCollection 2025 Mar.

DOI:10.1016/j.gendis.2024.101319
PMID:39634130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11615109/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/fc794c841b58/figs8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/2651ea614a73/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/7d92ffcff719/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/ba0ee1229f67/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/86d3f5a4575a/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/e6ae9079888b/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/a4ece050ad55/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/48369ead146f/figs6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/1fb2a44db547/figs7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/fc794c841b58/figs8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/2651ea614a73/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/7d92ffcff719/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/ba0ee1229f67/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/86d3f5a4575a/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/e6ae9079888b/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/a4ece050ad55/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/48369ead146f/figs6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/1fb2a44db547/figs7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db1/11615109/fc794c841b58/figs8.jpg

相似文献

1
PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma.PinX1通过抑制宫颈鳞状细胞癌和宫颈管腺癌中的端粒酶活性来抑制癌症进展。
Genes Dis. 2024 May 7;12(2):101319. doi: 10.1016/j.gendis.2024.101319. eCollection 2025 Mar.
2
PinX1, a novel target gene of p53, is suppressed by HPV16 E6 in cervical cancer cells.PinX1是p53的一个新的靶基因，在宫颈癌细胞中被HPV16 E6抑制。
Biochim Biophys Acta. 2014 Feb;1839(2):88-96. doi: 10.1016/j.bbagrm.2014.01.004. Epub 2014 Jan 8.
3
PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway.PinX1 通过抑制端粒酶活性和 p16/细胞周期蛋白 D1 通路抑制膀胱尿路上皮癌细胞增殖。
Mol Cancer. 2013 Nov 23;12(1):148. doi: 10.1186/1476-4598-12-148.
4
The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas.端粒/端粒酶结合因子PinX1根据纺锤体装配检查点调节人宫颈鳞状细胞癌对紫杉醇的敏感性。
Cancer Lett. 2014 Oct 10;353(1):104-14. doi: 10.1016/j.canlet.2014.07.012. Epub 2014 Jul 18.
5
Insufficient PINX1 expression stimulates telomerase activation by direct inhibition of EBV LMP1-NF-κB axis during nasopharyngeal carcinoma development.PINX1 表达不足通过直接抑制 EBV LMP1-NF-κB 轴在鼻咽癌发展过程中刺激端粒酶激活。
Biochem Biophys Res Commun. 2019 Jun 18;514(1):127-133. doi: 10.1016/j.bbrc.2019.04.104. Epub 2019 Apr 23.
6
The Pinx1 Gene Downregulates Telomerase and Inhibits Proliferation of CD133+ Cancer Stem Cells Isolated from a Nasopharyngeal Carcinoma Cell Line by Regulating Trfs and Mad1/C-Myc/p53 Pathways.Pinx1基因通过调控Trfs和Mad1/C-Myc/p53信号通路下调端粒酶并抑制从鼻咽癌细胞系分离出的CD133+癌干细胞的增殖。
Cell Physiol Biochem. 2018;49(1):282-294. doi: 10.1159/000492878. Epub 2018 Aug 23.
7
PinX1 regulation of telomerase activity and apoptosis in nasopharyngeal carcinoma cells.PinX1 对鼻咽癌细胞端粒酶活性和细胞凋亡的调控作用。
J Exp Clin Cancer Res. 2012 Feb 8;31(1):12. doi: 10.1186/1756-9966-31-12.
8
Expression and mechanism of PinX1 and telomerase activity in the carcinogenesis of esophageal epithelial cells.PinX1 的表达及其与端粒酶活性在食管上皮细胞癌变中的作用机制。
Oncol Rep. 2013 Oct;30(4):1823-31. doi: 10.3892/or.2013.2649. Epub 2013 Aug 1.
9
[Influence and mechanism of PinX1 gene on the chemotherapy sensitivity of nasopharyngeal carcinoma cells in response to Cisplatin].PinX1基因对鼻咽癌细胞顺铂化疗敏感性的影响及其机制
Zhonghua Yi Xue Za Zhi. 2015 Jun 23;95(24):1951-6.
10
PinX1 suppresses tumorigenesis by negatively regulating telomerase/telomeres in colorectal carcinoma cells and is a promising molecular marker for patient prognosis.PinX1通过负向调节结肠癌细胞中的端粒酶/端粒来抑制肿瘤发生，是一种很有前景的患者预后分子标志物。
Onco Targets Ther. 2016 Aug 3;9:4821-31. doi: 10.2147/OTT.S103141. eCollection 2016.

引用本文的文献

1
PINX1 inhibits proliferation and cisplatin resistance in nasopharyngeal carcinoma by promoting ILF3 ubiquitination.PINX1通过促进ILF3泛素化抑制鼻咽癌的增殖和顺铂耐药性。
Am J Cancer Res. 2025 Jun 15;15(6):2518-2534. doi: 10.62347/WFER2605. eCollection 2025.

本文引用的文献

1
Therapeutic strategies for targeting telomerase in cancer.针对癌症端粒酶的治疗策略。
Med Res Rev. 2020 Mar;40(2):532-585. doi: 10.1002/med.21626. Epub 2019 Jul 30.
2
Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation.端粒酶抑制剂 PinX1 将 TRF1 和端粒酶联系起来，以防止端粒延长。
J Biol Chem. 2011 Feb 4;286(5):3894-906. doi: 10.1074/jbc.M110.180174. Epub 2010 Nov 30.
3
HIV-Tat-mediated delivery of an LPTS functional fragment inhibits telomerase activity and tumorigenicity of hepatoma cells.
HIV-Tat 介导的 LPTS 功能片段的递呈抑制肝癌细胞的端粒酶活性和致瘤性。
Gastroenterology. 2011 Jan;140(1):332-43. doi: 10.1053/j.gastro.2010.08.046. Epub 2010 Nov 20.
4
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.TRF1和TRF2中用于差异募集端粒蛋白的共享对接基序。
Science. 2008 Feb 22;319(5866):1092-6. doi: 10.1126/science.1151804. Epub 2008 Jan 17.
5
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.与Pin2/TRF1相互作用的蛋白PinX1是一种有效的端粒酶抑制剂。
Cell. 2001 Nov 2;107(3):347-59. doi: 10.1016/s0092-8674(01)00538-4.