Waud B E, Waud D R
Anesth Analg. 1986 May;65(5):493-5.
The effect of immobilization of a limb on subsequent sensitivity of the diaphragm to d-tubocurarine was examined in the guinea pig. A forelimb was immobilized in a plaster cast for 1 or 3 weeks. An isolated nerve-diaphragm preparation was then set up and the sensitivity to d-tubocurarine measured. Parallel assays on a nerve-lumbrical muscle preparation from the limb in the cast were also examined for comparison. The diaphragm from unimmobilized animals showed the normal decreased sensitivity relative to the lumbrical. After immobilization the sensitivity of the lumbrical decreased, whereas that of the diaphragm did not change. Thus in contrast to previously observed behavior in limb muscles, changes in d-tubocurarine sensitivity produced by immobilization do not involve the diaphragm.
在豚鼠身上研究了肢体固定对膈随后对d - 筒箭毒碱敏感性的影响。将一侧前肢用石膏固定1周或3周。然后制备离体神经 - 膈标本，并测量其对d - 筒箭毒碱的敏感性。同时对固定肢体的神经 - 蚓状肌标本进行平行测定以作比较。未固定动物的膈相对于蚓状肌显示出正常的敏感性降低。固定后，蚓状肌的敏感性降低，而膈的敏感性未改变。因此，与先前在肢体肌肉中观察到的行为相反，固定引起的d - 筒箭毒碱敏感性变化并不涉及膈。
