Wang Tianyu, Li Zhi, Ma Tingting, Zhu Fengya, Yang Bin, Kim Sieun, Miao Runqing, Wu Jie
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Preventive Treatment, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Neurol. 2024 Nov 20;15:1403785. doi: 10.3389/fneur.2024.1403785. eCollection 2024.
Chronic Insomnia Disorder (CID) is highly prevalent among older adults and impairs cognitive function. Insomnia accelerates the progression of mild cognitive impairment (MCI) and increases the risk of developing dementia. Acupuncture has been demonstrated in improving sleep quality and cognitive function. This study aims to explore the functional brain characteristics of CID with MCI patients and to assess the effects of acupuncture therapy using functional near-infrared spectroscopy (fNIRS).
This study is a single-center randomized controlled trial. Participants will be randomly assigned to the manual acupuncture group or the placebo acupuncture group for an 8-week intervention period. fNIRS data will be collected during resting test and working memory test at baseline and at end of the intervention. The primary outcome is the change of the Montreal Cognitive Assessment (MoCA) score, secondary outcomes include the change of Mini-Mental State Examination (MMSE), Insomnia Severity Index (ISI), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7), and Apathy Evaluation Scale-Informant (AES-I).
The results of the study will provide insights into the effects of acupuncture on sleep quality and cognitive performance in CID with MCI patients. By utilizing fNIRS technology, we will elucidate the neural functional characteristic underlying the therapeutic benefits of acupuncture.
https://ClinicalTrials.gov, identifier ChiCTR2300076182.
慢性失眠障碍（CID）在老年人中高度流行，并损害认知功能。失眠会加速轻度认知障碍（MCI）的进展，并增加患痴呆症的风险。针灸已被证明可改善睡眠质量和认知功能。本研究旨在探索患有MCI的CID患者的大脑功能特征，并使用功能近红外光谱（fNIRS）评估针灸治疗的效果。
本研究是一项单中心随机对照试验。参与者将被随机分配到手动针灸组或安慰剂针灸组，进行为期8周的干预期。在基线和干预结束时的静息测试和工作记忆测试期间收集fNIRS数据。主要结局是蒙特利尔认知评估（MoCA）评分的变化，次要结局包括简易精神状态检查表（MMSE）、失眠严重程度指数（ISI）、患者健康问卷9项（PHQ-9）、广泛性焦虑障碍量表（GAD-7）和知情者冷漠评估量表（AES-I）的变化。
该研究结果将为针灸对患有MCI的CID患者的睡眠质量和认知表现的影响提供见解。通过利用fNIRS技术，我们将阐明针灸治疗益处背后的神经功能特征。
