Li Danping, Qian Xiaoqiong, Li Cong, Shi Song
Danping Li, Department of Otorhinolaryngology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 111 Xianxia Road, Shanghai, 200336, P.R. China.
Xiaoqiong Qian, Department of Otorhinolaryngology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 111 Xianxia Road, Shanghai, 200336, P.R. China.
Pak J Med Sci. 2024 Dec;40(11):2675-2680. doi: 10.12669/pjms.40.11.10417.
To explore the association between the levels of cyclooxygenase-2 (COX-2), aquaporin-1 (AQP1), pepsinogen I (PGI), and gastrin-17 (G17) and pathological features of laryngeal cancer (LC).
Clinical data of 120 patients with LC, treated in Shanghai Jiao Tong University School of Medicine from May 2022 to May 2023, as well as 120 healthy individuals who underwent physical examinations during the same period, were retrospectively analyzed. Serum levels of COX-2, AQP1, PGI, and G17 of LC patients and the healthy cohort were compared, and their association with pathological features of LC was investigated.
LC was associated with significantly higher serum levels of COX-2, AQP1, and G17 and lower of PGI compared to the control group (<0.05). Levels of COX-2, AQP1, and G17 positively correlated with the tumor, node and metastasis (TNM) staging, infiltration depth, and the lymph node metastases, and negatively correlated with the degree of differentiation (<0.05). There was a significant negative correlation between the level of PGI and TNM staging, infiltration depth, and lymph node metastases. PG1 also positively correlated with the degree of differentiation (<0.05). Area under curve (AUC) of combined COX-2, AQP1, PG-I, and G17 was significantly higher than that of each index alone (<0.05).
Levels of COX-2, AQP1, PGI, and G17 showed significant association with specific pathological features of LC. Serum levels of COX-2, AQP1, PGI, and G17 have certain predictive value for LC, and the combined predictive value of these four indicators is higher than that of a single indicator.
探讨环氧化酶-2（COX-2）、水通道蛋白-1（AQP1）、胃蛋白酶原I（PGI）和胃泌素-17（G17）水平与喉癌（LC）病理特征之间的关联。
回顾性分析2022年5月至2023年5月在上海交通大学医学院接受治疗的120例LC患者以及同期进行体检的120名健康个体的临床资料。比较LC患者和健康队列的血清COX-2、AQP1、PGI和G17水平，并研究它们与LC病理特征的关联。
与对照组相比，LC患者血清COX-2、AQP1和G17水平显著升高，PGI水平降低（<0.05）。COX-2、AQP1和G17水平与肿瘤、淋巴结转移（TNM）分期、浸润深度和淋巴结转移呈正相关，与分化程度呈负相关（<0.05）。PGI水平与TNM分期、浸润深度和淋巴结转移之间存在显著负相关。PG1与分化程度也呈正相关（<0.05）。COX-2、AQP1、PG-I和G17联合检测的曲线下面积（AUC）显著高于各指标单独检测（<0.05）。
COX-2、AQP1、PGI和G17水平与LC的特定病理特征显著相关。血清COX-2、AQP1、PGI和G17水平对LC具有一定的预测价值，这四项指标的联合预测价值高于单一指标。
