Intrator Jordan, Noto Jack, Vallesteros Renzmark D, Peltier Morgan, O'Reardon John, Abbas Muhammad
Psychiatry, NYU Langone Health, Brooklyn, USA.
Psychiatry, Hackensack Meridian School of Medicine, Nutley, USA.
Cureus. 2024 Nov 4;16(11):e72993. doi: 10.7759/cureus.72993. eCollection 2024 Nov.
Many patients are taking psychotropic medications concomitantly with repetitive transcranial magnetic stimulation (rTMS), the latter of which is indicated for the treatment of moderate and severe depressive episodes that have not responded to first-line pharmacotherapy. While preclinical evidence suggests that psychotropic drugs can generally affect rTMS, the specific effect on the clinical response of rTMS for depression is not fully clear. A systematic search of all papers published prior to January 2023 in PubMed, APA, PsycInfo, and Scopus was conducted to identify clinical studies that examine the effects of different psychotropic medications on clinical outcomes in patients undergoing rTMS for depression. A total of 10 articles were identified and extracted for inclusion. This review outlines the results from 10 clinical studies and summarizes the current state of the literature describing rTMS outcomes with concomitant use of several groups of psychotropic agents, including antipsychotics, mood stabilizers, psychostimulants, and benzodiazepines. Antidepressants were excluded from this review due to the evidence base that already exists describing their efficacy with and without rTMS.
许多患者在接受重复经颅磁刺激（rTMS）治疗的同时还在服用精神药物，rTMS适用于治疗对一线药物治疗无反应的中度和重度抑郁发作。虽然临床前证据表明精神药物通常会影响rTMS，但对rTMS治疗抑郁症临床反应的具体影响尚不完全清楚。我们对2023年1月之前在PubMed、APA、PsycInfo和Scopus上发表的所有论文进行了系统检索，以确定研究不同精神药物对接受rTMS治疗抑郁症患者临床结局影响的临床研究。共识别并提取了10篇文章纳入研究。本综述概述了10项临床研究的结果，并总结了目前关于同时使用几类精神药物（包括抗精神病药物、心境稳定剂、精神兴奋剂和苯二氮䓬类药物）时rTMS治疗结局的文献现状。由于已有关于抗抑郁药在有或无rTMS情况下疗效的证据基础，因此本综述将抗抑郁药排除在外。
