Lück Martin, Klinken-Uth Stefan, Kleinebudde Peter
Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutics and Biopharmaceutics, Universitaetsstrasse 1, 40225 Düsseldorf, Germany.
Int J Pharm X. 2024 Nov 14;8:100303. doi: 10.1016/j.ijpx.2024.100303. eCollection 2024 Dec.
Elastic recovery ( ) has been investigated and discussed extensively in the field of tableting. However, until now only limited data is available regarding in roll compaction. Therefore, a previously established in-line measurement technique was rolled out to further investigate the kinetics of in roll compaction and the effects of specific compaction force ( ) and roll speed ( ). In-line laser triangulation measurements at different positions within a roll rotation as well as measurement over time after the process has been stopped were utilized. Pure microcrystalline cellulose ( ) and two placebo powder blend formulations were analysed. Successful fit of the contained profiles emphasized that the on the roll surface is build out of two exponential kinetics. Starting with a dominating fast ( ), characterized by a high increase of the ribbon thickness after passing the gap width, followed by a slower ( ). Sigma minus plot analysis showed that increasing led to an accelerated and which was related to the viscoelastic behaviour of . The only had an effect on the kinetics of if a brittle filler was added to the mixture. The conducted study established the first approach in literature to characterize the kinetics of in roll compaction. It supports the understanding and characterization of relaxation times and the effect of the and in roll compaction.
弹性回复（ ）在压片领域已得到广泛研究和讨论。然而，迄今为止，关于辊压过程中的弹性回复仅有有限的数据。因此，采用了一种先前建立的在线测量技术，以进一步研究辊压过程中弹性回复的动力学以及特定压实力（ ）和辊速（ ）的影响。利用了在辊子旋转过程中不同位置的在线激光三角测量以及过程停止后的随时间测量。对纯微晶纤维素（ ）和两种安慰剂粉末混合配方进行了分析。所包含的弹性回复曲线的成功拟合强调，辊表面的弹性回复由两种指数动力学构成。首先是占主导地位的快速弹性回复（ ），其特征是通过间隙宽度后带材厚度大幅增加，随后是较慢的弹性回复（ ）。西格玛减图分析表明，增加压实力会导致快速和慢速弹性回复加速，这与物料的粘弹性行为有关。只有在混合物中添加脆性填料时，辊速才会对弹性回复动力学产生影响。所进行的研究建立了文献中第一种表征辊压过程中弹性回复动力学的方法。它有助于理解和表征松弛时间以及压实力和辊速在辊压过程中的影响。
