Treechairusame Teeradon, Taweesedt Pahnwat T
Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, United States.
World J Radiol. 2024 Nov 28;16(11):696-699. doi: 10.4329/wjr.v16.i11.696.
In this article, we comment on the article by Ono . We focus specifically on the carbon ion radiotherapy studies and the method to calculate the dosing schedule. While photon hypofractionated radiotherapy in prostate cancer has demonstrated improvement in tumor control with reduced gastrointestinal toxicity compared to conventional radiotherapy, carbon ion radiotherapy (CIRT) offers additional physical and biological advantages. Recent findings, including those from Ono , have established new dose constraints of CIRT for prostate cancer treatment and risk factors for rectal bleeding. Due to limited data on CIRT dosing, this study underscores the need for more research to refine dose calculation methods and better understand their effects on clinical outcomes.
在本文中，我们对小野的文章进行评论。我们特别关注碳离子放射治疗研究以及剂量计划的计算方法。虽然前列腺癌的光子低分割放射治疗已证明与传统放射治疗相比，在肿瘤控制方面有所改善，且胃肠道毒性降低，但碳离子放射治疗（CIRT）具有额外的物理和生物学优势。包括小野等人的研究结果在内的近期发现，已经确立了CIRT用于前列腺癌治疗的新剂量限制以及直肠出血的风险因素。由于关于CIRT剂量的数据有限，本研究强调需要更多研究来完善剂量计算方法，并更好地了解其对临床结果的影响。
