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骨化性气管支气管病:一名63岁男性的临床病例报告

Tracheobronchopathia osteoplastica: a clinical case report of a 63-year-old man.

作者信息

Lai Jing, Deng Yingli, He Qingmin

机构信息

Second Ward, Department of Respiratory and Critical Care Medicine, Ankang Central Hospital, Ankang, China.

Department of Gastroenterology, Ankang Central Hospital, Ankang, Shaanxi, China.

出版信息

Front Med (Lausanne). 2024 Nov 20;11:1410724. doi: 10.3389/fmed.2024.1410724. eCollection 2024.

Abstract

Tracheobronchopathia osteoplastica (TO) is a rare benign lesion of the airways, characterized by multiple nodular proliferations of bone and/or cartilaginous tissue in the submucosa of the trachea and bronchi. In this paper, we present a case of a 63-year-old male patient who was admitted to the hospital due to cough and blood in his sputum. The patient was diagnosed with TO through examination and pathological biopsy. The exact pathogenesis of this disease remains unclear, but it may be related to multiple factors such as chronic infection and inflammation. The clinical manifestations are diverse, with no symptoms or only mild cough in the early stage, and persistent cough, dyspnea, and other symptoms may appear as the disease progresses. Diagnosis mainly relies on pathological biopsy, while treatment is mainly symptomatic, including inhalation of glucocorticoids, airway interventional therapy, and stent placement. Overall, TO progresses slowly and has a good prognosis, but early diagnosis and elimination of predisposing factors are crucial for treatment.

摘要

气管支气管骨化症(TO)是一种罕见的气道良性病变,其特征是气管和支气管黏膜下层出现多个骨和/或软骨组织的结节状增生。本文报告一例63岁男性患者,因咳嗽和痰中带血入院。经检查及病理活检,该患者被诊断为气管支气管骨化症。本病的确切发病机制尚不清楚,但可能与慢性感染和炎症等多种因素有关。其临床表现多样,早期可无任何症状或仅有轻微咳嗽,随着病情进展,可出现持续性咳嗽、呼吸困难等症状。诊断主要依靠病理活检,治疗主要为对症治疗,包括吸入糖皮质激素、气道介入治疗及支架置入等。总体而言,气管支气管骨化症进展缓慢,预后良好,但早期诊断及消除诱发因素对治疗至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/244c/11616475/d37686997411/fmed-11-1410724-g001.jpg

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