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氟代脱氧葡萄糖正电子发射断层扫描(FDG PET)能否作为检测活动性非结节病性心肌炎的临床相关工具?

Can FDG PET Serve as a Clinically Relevant Tool for Detecting Active Non-sarcoidotic Myocarditis?

作者信息

Cho Sang-Geon

机构信息

Department of Nuclear Medicine, Chonnam National University Hospital, 42, Jebong-ro, Dong-gu, Gwangju, 61469 Republic of Korea.

出版信息

Nucl Med Mol Imaging. 2024 Dec;58(7):406-417. doi: 10.1007/s13139-023-00827-0. Epub 2023 Oct 31.

DOI:10.1007/s13139-023-00827-0
PMID:39635631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11612073/
Abstract

The diagnostic work-up for myocarditis largely depends on non-invasive imaging because of the low yield of endomyocardial biopsy. In addition, differentiation among possible impressions is essential because of its non-specific clinical presentations. This ambiguity has led to the predominant use of cardiac magnetic resonance imaging techniques in the management of myocarditis, particularly during the global pandemic. Despite the unique ability of F-18 fluorodeoxyglucose positron emission tomography to visualize and quantify active myocardial inflammation, which has been well established in cardiac sarcoidosis, its diagnostic contribution in non-sarcoidotic myocarditis remains uncertain. This article reviews the current evidence on the non-invasive imaging diagnosis of non-sarcoidotic myocarditis and discusses the potential role of F-18 fluorodeoxyglucose positron emission tomography as a clinically relevant imaging tool.

摘要

由于心内膜心肌活检的阳性率较低,心肌炎的诊断检查很大程度上依赖于非侵入性成像。此外,鉴于心肌炎临床表现不具特异性,区分可能的诊断结果至关重要。这种不确定性导致在心肌炎的管理中,尤其是在全球大流行期间,心脏磁共振成像技术得到了广泛应用。尽管F-18氟脱氧葡萄糖正电子发射断层扫描在可视化和量化活动性心肌炎症方面具有独特能力,这在心脏结节病中已得到充分证实,但其在非结节病性心肌炎中的诊断作用仍不确定。本文综述了非结节病性心肌炎非侵入性成像诊断的当前证据,并讨论了F-18氟脱氧葡萄糖正电子发射断层扫描作为一种临床相关成像工具的潜在作用。

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JACC Cardiovasc Imaging. 2024 Jan;17(1):45-58. doi: 10.1016/j.jcmg.2023.05.017. Epub 2023 Jul 12.
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Meta-analysis of the effectiveness of heparin in suppressing physiological myocardial FDG uptake in PET/CT.肝素抑制 PET/CT 中生理性心肌 FDG 摄取的有效性的荟萃分析。
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Myocardial Inflammation on FDG PET/MRI and Clinical Outcomes in Symptomatic and Asymptomatic Participants after COVID-19 Vaccination.COVID-19疫苗接种后有症状和无症状参与者的FDG PET/MRI心肌炎症及临床结局
Radiol Cardiothorac Imaging. 2023 Mar 9;5(2):e220247. doi: 10.1148/ryct.220247. eCollection 2023 Apr.
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Cardiovascular magnetic resonance for evaluation of cardiac involvement in COVID-19: recommendations by the Society for Cardiovascular Magnetic Resonance.心血管磁共振在评估 COVID-19 心脏受累中的应用:心血管磁共振学会的建议。
J Cardiovasc Magn Reson. 2023 Mar 27;25(1):21. doi: 10.1186/s12968-023-00933-0.
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The characteristics of Japanese guidelines on diagnosis and treatment of cardiac sarcoidosis compared with the previous guidelines.日本心脏结节病诊断与治疗指南与既往指南相比的特点。
Sarcoidosis Vasc Diffuse Lung Dis. 2022;39(3):e2022028. doi: 10.36141/svdld.v39i3.12531. Epub 2022 Sep 23.
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